FIZ1

FLT3 interacting zinc finger 1 is a protein that in humans is encoded by the FIZ1 gene.

FIZ1
Identifiers
Aliases	FIZ1, ZNF798, FLT3 interacting zinc finger 1
External IDs	OMIM: 609133 MGI: 1344336 HomoloGene: 22663 GeneCards: FIZ1
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 55,591,376 bp End 55,601,970 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 5,010,058 bp End 5,017,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventral tegmental area cardia tibialis anterior muscle subthalamic nucleus external globus pallidus body of tongue inferior ganglion of vagus nerve medulla oblongata superior vestibular nucleus pericardium Top expressed in Bowman's capsule internal carotid artery medial ganglionic eminence external carotid artery primitive streak interventricular septum temporal muscle secondary oocyte right ventricle ankle More reference expression data BioGPS n/a
Gene ontology Molecular function receptor tyrosine kinase binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process positive regulation of protein phosphorylation regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84922 23877 Ensembl ENSG00000179943 ENSMUSG00000061374 UniProt Q96SL8 Q9WTJ4 RefSeq (mRNA) NM_032836 NM_001110328 NM_001110329 NM_001110330 NM_011813 NM_001360241 NM_001360242 NM_001360243 RefSeq (protein) NP_116225 NP_001103798 NP_001103799 NP_001103800 NP_035943 NP_001347170 NP_001347171 NP_001347172 Location (UCSC) Chr 19: 55.59 – 55.6 Mb Chr 7: 5.01 – 5.02 Mb PubMed search
Wikidata
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Function

This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008].

Further reading

• Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, Swaroop A (February 2003). "Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor". Hum. Mol. Genet. 12 (4): 365–73. doi:10.1093/hmg/ddg035. PMID 12566383.
• Mali RS, Zhang X, Hoerauf W, Doyle D, Devitt J, Loffreda-Wren J, Mitton KP (February 2007). "FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro". Exp. Eye Res. 84 (2): 349–60. doi:10.1016/j.exer.2006.10.009. PMC 5066392. PMID 17141759.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.