F53 may refer to:
- F53 (classification), a disability sport classification
- English Electric Lightning F.53, a British fighter aircraft
- Franklin County Airport (Texas)
- HMS Ausonia (F53), a Cunard ocean liner requisitioned for the Royal Navy
- HMS Janus (F53), a J-class destroyer of the Royal Navy
- HMS Undaunted (F53), a U-class destroyer of the Royal Navy
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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