Dihydroxyphenylglycine
| Dihydroxyphenylglycine | |
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(S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
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Other names
3,5-dihydroxyphenylglycine, DHPG, S-DHPG |
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| Identifiers | |
| CAS number | 162870-29-3 |
| PubChem | 5310986 |
| ChemSpider | 11377133  |
| MeSH | 3,5-dihydroxyphenylglycine |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C8H9N1O4 |
| Molar mass | 183.05 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5.
DHPG was the first agonist shown to be selective for group I mGluRs.[1] Agonist activity is found in only the (S)-isomer, and (S)-DHPG may be a partial agonist of group I mGluRs.[1]
(S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease.[1]
3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia.[2]
References
- ^ a b c Wiśniewski K.; Car, H. (2002). "(S)-3,5-DHPG: a review". CNS Drug Rev. 8 (1): 101–116. PMID 12070529.
- ^ Müller, P.; Schütte, H. R. (May 1968). "m-Hydroxyphenylglycine and 3,5-dihydroxyphenylglycine, 2 new amino acids from the latex of Euphorbia helioscopia". Z. Naturforsch. B (in German) 23 (5): 659–663. PMID 4385921.
