Denaverine

Denaverine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Gr 1 (Germany);
Routes of; administration	intramuscular injection, suppositories
ATCvet code	QG02CX90 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	8% (suppositories),; 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
	IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate;
CAS Number	3579-62-2 ; 3321-06-0 (hydrochloride);
PubChem CID	71130;
ChemSpider	64278 ;
UNII	O14NF38MTL;
KEGG	D07787 ;
ChEMBL	ChEMBL1614656 ;
CompTox Dashboard (EPA)	DTXSID10189315 ;
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.532 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C;
	InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 ; Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N ;
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Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Mechanism of action edit

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]

References edit

^ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
^ Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
^ Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

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[1] Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report

[2] Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.

[Arzneistoff-Profile-3] Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

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[2]

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Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
ATCvet code	QG02CX90 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number	3579-62-2^Y 3321-06-0 (hydrochloride)
PubChem CID	71130
ChemSpider	64278^N
UNII	O14NF38MTL
KEGG	D07787^Y
ChEMBL	ChEMBL1614656^N
CompTox Dashboard (EPA)	DTXSID10189315
Chemical and physical data
Formula	C₂₄H₃₃NO₃
Molar mass	383.532 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3^N Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N^N
^NY (what is this?) (verify)