DDX43

Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene.

DDX43
Identifiers
Aliases	DDX43, CT13, HAGE, DEAD-box helicase 43
External IDs	OMIM: 606286 MGI: 3642857 HomoloGene: 56814 GeneCards: DDX43
Gene location (Human) Chr. Chromosome 6 (human) Band 6q13 Start 73,394,828 bp End 73,417,566 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 78,303,059 bp End 78,330,869 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm Achilles tendon gastric mucosa right coronary artery placenta thoracic aorta right lung ascending aorta Top expressed in spermatocyte seminiferous tubule spermatid morula blastocyst conjunctival fornix fossa esophagus vas deferens ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding hydrolase activity nucleotide binding nucleic acid binding helicase activity RNA binding Cellular component intracellular anatomical structure nucleolus cytoplasm Biological process RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55510 100048658 Ensembl ENSG00000080007 ENSMUSG00000070291 UniProt Q9NXZ2 D3Z6P9 RefSeq (mRNA) NM_018665 NM_001191044 RefSeq (protein) NP_061135 NP_001177973 Location (UCSC) Chr 6: 73.39 – 73.42 Mb Chr 9: 78.3 – 78.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD box family and displays tumor-specific expression.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Nagel H, Laskawi R, Eiffert H, Schlott T (2003). "Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands". Mol. Pathol. 56 (4): 226–31. doi:10.1136/mp.56.4.226. PMC 1187325. PMID 12890744.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE (2007). "HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides". Cancer Immunol. Immunother. 56 (12): 1885–95. doi:10.1007/s00262-007-0331-2. PMC 11030838. PMID 17487488. S2CID 5801595.