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Clive Sherlock is a British doctor who trained in cognitive behavioural therapy and Jungian psychoanalysis during postgraduate studies at Oxford. He saw limitations in the theories and uses of psychotherapy, cognitive behavioural therapy and psychotropic medication, recognising that we do not understand the nature and cause of conditions such as clinical depression, anxiety, anger and stress, which is why experts are still searching for ways of treating them. As well as studies and work in conventional medicine and psychology he also made a specialised study of far eastern psychology and philosophy, particularly that of Buddhism, and in 1977 he introduced mindfulness meditation as part of a structured training programme for people facing anything from mild to the most severe psychological and emotional difficulties. These included bipolar, major depression, anxiety, panic, obsessive-compulsive disorder and eating disorders and related conditions.
He called this approach Adaptation Practice. By Adaptation he means a psychological process that changes our attitudes, habitual responses and outward behaviour to be in harmony with the requirements of any situation we are in. Adaptation requires fundamental changes in how we react to underlying emotions that give rise to psychological problems and that impede or obstruct optimal performance in day-to-day activities, in relationships, at home and at work. Adaptation therefore affects motivation and cooperation. Adaptation results in changes in the nature of emotion before it gives rise to changes in the body (fast heart, tension, rage or weeping, for example) and mind (tense and impelling thoughts driven by the emotion and therefore being depressed, anxious, angry or sad, for example).
Sherlock first taught Adaptation Practice to people coming to the Oxford University Clinic with treatment-resistant depression and anxiety in 1977. It soon became apparent that it helped people with any problem that involved how they felt, such as: depression, anxiety, anger, stress, obsessive-compulsive disorder and eating disorders. As well as this Adaptation Practice is taken up by professionals, business executives, professional athletes and performing artists to enhance their performance in their special fields. He has continued to teach Adaptation Practice to people with a wide range of conditions and difficulties, from all walks of life and from different cultural, religious, political and philosophical backgrounds. He also trains doctors, psychologists and neuroscientists to teach Adaptation Practice. In 1985 he started teaching Adaptation Practice by distance learning internationally: email, telephone and more recently by Skype.
Having studied medicine in London at Charing Cross Hospital Medical School, Imperial College, London, UK, and worked for three years in teaching hospitals he went to Heidelberg University to study philosophy under Professor Ernst Tugendhat. On his return to the UK he started his studies of the psychology and philosophy of monastic Zen under Venerable Myokyo-ni, shortly before starting postgraduate training in psychiatry and psychology in London under Professor Steven Hirsch at Charing Cross Hospital. While in London he trained in behaviour therapy with Dr Robert Liberman and then continued his training at Oxford University departments of psychiatry and psychology under Professor Michael Gelder. At Oxford Sherlock trained in cognitive behavioural therapy and in Jungian analytical psychotherapy with Dr Anthony Storr.
In 1999 The Times newspaper published a feature article on Adaptation Practice. 
Sherlock has published articles on Western and Eastern philosophy and psychology related to A. N. Whitehead's process philosophy and is a founding member of the Whitehead Psychology Nexus, a web-based research group bridging East-West psychologies and philosophies. He taught Buddhist psychology and philosophy for a number of years at The Buddhist Society in London and has written articles for The Buddhist Society’s journal The Middle Way.
- A New Psychological Model of the Psyche with Special Relevance to Depression, Anxiety, Anger, and Stress by Clive Sherlock: presented at the 4th International Conference on Philosophy and Psychiatry in Florence August 2000.
- Riffert, Franz; Weber, Michel (2003). "The Universality of Impermanence". Searching for New Contrasts. Frankfurt am Main: Peter Lang. pp. 231–242. ISBN 978-3-631-39089-4.
- Derfer, et al, George (2009). "On Zen Buddhism". The Roar of Awakening. Heusestamm: ontos verlag. pp. 225–236. ISBN 978-3-86838-039-2.
- "The Four Nobel Truths". The Middle Way. 3 71: 160–165. November 1996.
- "Three Refuges, Signs of Being and Fires". The Middle Way. 4 71: 229–239. February 1997.
- "Dharmas, Dhatus, Skandhas". The Middle Way. 3 72: 131–141. November 1997.
- "Transformation Through Practice". The Middle Way. 1 72: 21–29. May 1997.
- "The Wheel of Birth ad Death". The Middle Way. 1 73: 23–30. May 1998.
- "Karma and Rebirth". The Middle Way. 2 73: 81–86. August 1998.
- Ahuja, Anjana (February 1999). "Train your mind to fight depression". The Times. p. 14.