Class 350 may refer to:
- British Rail Class 350, a class of electric multiple-unit passenger trains built by Siemens
- Renfe Class 350, a series of single-cabin diesel locomotives in Spain built in the U.S. by the American Car and Foundry company
- Talgo 350, a Spanish high-speed train
- South Australian Railways 350 class, two diesel-electric locomotives built by the Islington Railway Workshops
This disambiguation page lists articles associated with the title Class 350.
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