Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene .[5] [6] [7]
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP , RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[7]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000120318 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024451 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices" . Mol Cell . 9 (1): 95–108. doi :10.1016/S1097-2765(02)00434-3 PMID 11804589 . ^ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho" . Curr Biol . 12 (10): R360–2. Bibcode :2002CBio...12.R360S . doi :10.1016/S0960-9822(02)00860-6 PMID 12015138 . S2CID 15875666 . ^ a b "Entrez Gene: CENTD3 centaurin, delta 3" .
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Further reading
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Raaijmakers JH, Deneubourg L, Rehmann H, De Koning J, Zhang Z, Krugmann S, et al. (2007). "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner". Cell. Signal . 19 (6): 1249–57. doi :10.1016/j.cellsig.2006.12.015 . hdl :1874/35664 PMID 17314030 . S2CID 356352 . Lu Q, Wei W, Kowalski PE, Chang AC, Cohen SN (2005). "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin" . Proc. Natl. Acad. Sci. U.S.A . 101 (49): 17246–51. doi :10.1073/pnas.0407794101 PMC 534609 PMID 15569923 . I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, et al. (2005). "ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner" . J. Cell Sci . 117 (Pt 25): 6071–84. doi :10.1242/jcs.01526 PMID 15546919 . Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Reinhard C, Schweikert M, Wieland FT, Nickel W (2003). "Functional reconstitution of COPI coat assembly and disassembly using chemically defined components" . Proc. Natl. Acad. Sci. U.S.A . 100 (14): 8253–7. Bibcode :2003PNAS..100.8253R . doi :10.1073/pnas.1432391100 PMC 166215 PMID 12832619 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
