CENTD1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

ARAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X40, 2COD
Identifiers
Aliases	ARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDs	OMIM: 606645 MGI: 2684416 HomoloGene: 9064 GeneCards: ARAP2
Gene location (Human) Chr. Chromosome 4 (human) Band 4p14 Start 35,948,221 bp End 36,244,514 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 C3.1 Start 62,759,788 bp End 62,923,502 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte corpus callosum optic nerve amniotic fluid internal globus pallidus middle temporal gyrus Brodmann area 23 germinal epithelium inferior olivary nucleus Top expressed in secondary oocyte medial geniculate nucleus hair follicle Region I of hippocampus proper primary motor cortex lateral geniculate nucleus inferior colliculus piriform cortex medial dorsal nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding Cellular component cytoplasm cytosol Biological process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116984 212285 Ensembl ENSG00000047365 ENSMUSG00000037999 UniProt Q8WZ64 Q8BZ05 RefSeq (mRNA) NM_015230 NM_139182 NM_178407 RefSeq (protein) NP_056045 n/a Location (UCSC) Chr 4: 35.95 – 36.24 Mb Chr 5: 62.76 – 62.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.

External links

• Human ARAP2 genome location and ARAP2 gene details page in the UCSC Genome Browser.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA (November 2006). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". Journal of Cell Science. 119 (Pt 22): 4650–66. doi:10.1242/jcs.03237. PMID 17077126.
• Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA (January 2002). "ARAP1: a point of convergence for Arf and Rho signaling". Molecular Cell. 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
• Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (January 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.