Wikipedia

Brigitte Askonas

Brigitte Alice Askonas FRS FMedSci (1 April 1923 – 9 January 2013)[4] was a British immunologist[6] and a visiting professor at Imperial College London from 1995.[2][7][8]

Brigitte Askonas
FRS FMedSci
Born
Brigitte Alice Askonas

(1923-04-01)1 April 1923
Vienna, Austria
Died9 January 2013(2013-01-09) (aged 89)
Alma materMcGill University (BSc, MSc)
University of Cambridge (PhD)
AwardsRobert Koch Prize (2007)
Member of the National Academy of Sciences (2007)[1]
Scientific career
InstitutionsJohn Radcliffe Hospital
University of Cambridge
Harvard Medical School[2]
Imperial College London
McGill University
National Institute for Medical Research
ThesisThe separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase (1952)
Doctoral advisorMalcolm Dixon[3]
Doctoral studentsMichael J. Bevan
Andrew McMichael[4]
Alain Townsend[5]

Education edit

Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. Vienna-born Askonas studied biochemistry at McGill University (BSc, MSc) and carried out her postgraduate work in the school of biochemistry at the University of Cambridge where she was a student of Girton College, Cambridge.[3][8][9][10][11]

Her role models in the department included two distinguished scientists, Marjory Stephenson and Dorothy Needham,[citation needed] two of the first women to be elected to the Royal Society. She said they taught her that "good science gets recognition regardless of the sex of the scientist". Her PhD research was supervised by Malcolm Dixon.[4][3][9]

Career and research edit

Her first position was at the Allan Memorial Institute of Psychiatry (associated with McGill University).[9] In 1952, she joined the staff of the National Institute for Medical Research (NIMR) where she served as head of the division of Immunology from 1976 to 1988.[12][13]

During that time, she worked extensively with fellow immunologist John H. Humphrey to establish the immunology divisions. Askonas focused on B cells and determined their role in producing antibodies as part of the immune response.

At the NIMR she began researching the biosynthesis of polypeptides in milk proteins discovering that the peptides were synthesised from amino acids rapidly in one piece.[9] From 1955-59 she studied the sites of antibody formation using radioactivity to develop our understanding of antibody molecules and the cells of the immune system. From 1959-61 she studied plasma cell tumors as models for antibody formation. She went on to investigate macrophages and their role in antigen presentation (1962–1968). From 1963 to 1966 she studied the fate of antigen in relation to antibody formation and later continued her study of B cells from 1965 to 1970.[9]

She wrote several biographies of high-profile scientists, including Niels Kaj Jerne,[14] César Milstein[15] and John Herbert Humphrey.[16] Askonas conducted a filmed interview with Stanley Peart as a segment of what became the Medical Sciences Video Archive[17] housed in the special collections of the library at Oxford Brookes University.

Awards and honours edit

In 2007 she was made a foreign associate of the National Academy of Sciences of the United States[1][18] and won the Robert Koch Prize.[4] She was also elected a Fellow of the Royal Society (FRS) in 1973[4] and a Fellow of the Academy of Medical Sciences (FMedSci).[when?]

References edit

  1. ^ a b "Brigitte Askonas". www.nasonline.org.
  2. ^ a b Anon (2013). "Askonas, Brigitte Alice (Ita)". Who's Who & Who Was Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U5882. (Subscription or UK public library membership required.)
  3. ^ a b c Askonas, Brigitte (1952). The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase (PhD thesis). University of Cambridge. ProQuest 301230275.
  4. ^ a b c d e McMichael, Andrew J.; Ogilvie, Bridget M. (2018). "Brigitte Alice Askonas. 1 April 1923—9 January 2013". Biographical Memoirs of Fellows of the Royal Society. 65: 31–45. doi:10.1098/rsbm.2018.0007. ISSN 0080-4606. S2CID 81086759.
  5. ^ Townsend, Alain Robert Michael (1984). Recognition of influenza virus specific cytotoxic T cell clones. london.ac.uk (PhD thesis). University of London. OCLC 941030873. Copac 34553445.
  6. ^ "Lists of Royal Society Fellows 1660–2007". London, UK: The Royal Society. Retrieved 6 July 2012.
  7. ^ "Imperial College London - 2000 Fellows of Imperial College". Retrieved 16 March 2016.
  8. ^ a b O'Garra, Anne (2013). "Brigitte Askonas (1923–2013)". Nature. 494 (7435): 37. Bibcode:2013Natur.494...37O. doi:10.1038/494037a. PMID 23389536.
  9. ^ a b c d e Askonas, Brigitte Alice (1990). "From Protein Synthesis to Antibody formation and Cellular Immunity: A Personal View". Annual Review of Immunology. 8 (1): 1–22. doi:10.1146/annurev.iy.08.040190.000245. PMID 2188659.
  10. ^ Anon (4 April 2013). "Professor Brigitte Askonas Obituary". telegraph.co.uk. The Daily Telegraph.
  11. ^ Ogilvie, Bridget (10 January 2013). "Obituary for Brigitte Askonas". The Guardian.
  12. ^ Askonas, B.A.; Rhodes, J.M. (1965). "Immunogenicity of Antigen-Containing Ribonucleic Acid Preparations from Macrophages". Nature. 205 (4970): 470–4. Bibcode:1965Natur.205..470A. doi:10.1038/205470a0. PMID 14269699. S2CID 27657849.
  13. ^ McMichael, A.J.; Ting, A.; Zweerink, H.J.; Askonas, B.A. (1977). "HLA restriction of cell-mediated lysis of influenza virus-infected human cells". Nature. 270 (5637): 524–26. Bibcode:1977Natur.270..524M. doi:10.1038/270524a0. PMID 593371. S2CID 4173925.
  14. ^ Askonas, B. A.; Howard, J. G. (1997). "Niels Kaj Jerne. 23 December 1911--7 October 1994.: Elected F.R.S 1980". Biographical Memoirs of Fellows of the Royal Society. 43: 237–251. doi:10.1098/rsbm.1997.0013. S2CID 45810507.
  15. ^ Neuberger, M. S.; Askonas, B. A. (2005). "Cesar Milstein CH. 8 October 1927 - 24 March 2002: Elected F.R.S. 1974". Biographical Memoirs of Fellows of the Royal Society. 51: 267. doi:10.1098/rsbm.2005.0017.
  16. ^ Askonas, B.A. (1990). "John Herbert Humphrey. 16 December 1915-25 December 1987". Biographical Memoirs of Fellows of the Royal Society. 36: 274–300. doi:10.1098/rsbm.1990.0033. PMID 11616175.
  17. ^ "Medical Sciences Video Archive".
  18. ^ Anon (2007). "72 new members chosen by the Academy". nationalacademies.org. Retrieved 16 March 2016.
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