BAT2

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.

PRRC2A
Identifiers
Aliases	PRRC2A, BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDs	OMIM: 142580 MGI: 1915467 HomoloGene: 10567 GeneCards: PRRC2A
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,620,715 bp End 31,637,771 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.59 cM Start 35,368,052 bp End 35,383,873 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary ganglionic eminence prostate left uterine tube right uterine tube amygdala spleen right lobe of thyroid gland left lobe of thyroid gland Top expressed in superior frontal gyrus lip superior surface of tongue gallbladder yolk sac habenula cerebellar cortex spermatocyte dorsomedial hypothalamic nucleus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component extracellular exosome membrane nucleus cytoplasm nucleoplasm cytosol plasma membrane Biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7916 53761 Ensembl ENSG00000204469 ENSG00000206427 ENSG00000231825 ENSG00000231370 ENSG00000226618 ENSG00000225164 ENSG00000225748 ENSMUSG00000024393 UniProt P48634 Q7TSC1 RefSeq (mRNA) NM_004638 NM_080686 NM_001199044 NM_020027 RefSeq (protein) NP_004629 NP_542417 NP_001185973 NP_064411 Location (UCSC) Chr 6: 31.62 – 31.64 Mb Chr 17: 35.37 – 35.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.

Interactions

BAT2 has been shown to interact with:

• C1QBP,
• EIF3S6,
• HNRNPA1,
• IFT88,
• IMMT, and
• UBAP2L.

Further reading

• Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Singal DP, Li J, Zhu Y (2000). "HLA class III region and susceptibility to rheumatoid arthritis". Clin. Exp. Rheumatol. 18 (4): 485–91. PMID 10949724.
• Hashimoto M, Nakamura N, Obayashi H, et al. (2000). "Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus". Hum. Genet. 105 (3): 197–9. doi:10.1007/s004390051089 (inactive 2024-03-15). PMID 10987645.{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link)
• Matsuzaka Y, Makino S, Nakajima K, et al. (2002). "New polymorphic microsatellite markers in the human MHC class III region". Tissue Antigens. 57 (5): 397–404. doi:10.1034/j.1399-0039.2001.057005397.x. PMID 11556964.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schneiders A, Thiel S, Winkler J, et al. (2005). "Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide". Vaccine. 23 (19): 2540–50. doi:10.1016/j.vaccine.2004.08.003. PMID 15752841.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Human PRRC2A genome location and PRRC2A gene details page in the UCSC Genome Browser.