Andrew O'Shaughnessy may refer to:
- Andrew O'Shaughnessy (politician) (1866–1956), Irish politician and businessman, independent TD for Cork Borough 1923–1927
- Andrew O'Shaughnessy (historian) (born 1959), British historian
- Andrew O'Shaughnessy (hurler) (born 1984), Irish hurler for Kilmallock Limerick
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