ASB3

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.

ASB3
Identifiers
Aliases	ASB3, ASB-3, ankyrin repeat and SOCS box containing 3
External IDs	OMIM: 605760 MGI: 1929749 HomoloGene: 9391 GeneCards: ASB3
Gene location (Human) Chr. Chromosome 2 (human) Band 2p16.2 Start 53,532,672 bp End 53,860,160 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A4|11 18.19 cM Start 30,835,416 bp End 31,052,704 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence middle temporal gyrus endothelial cell tibia corpus callosum entorhinal cortex postcentral gyrus superior frontal gyrus Achilles tendon Top expressed in spermatocyte endocardial cushion medial ganglionic eminence spermatid cumulus cell otic placode blood atrioventricular valve calvaria thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin protein ligase binding ubiquitin-protein transferase activity Cellular component cytoplasm nucleus ubiquitin ligase complex cytosol Biological process protein ubiquitination intracellular signal transduction post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51130 65257 Ensembl ENSG00000115239 ENSMUSG00000020305 UniProt Q9Y575 Q9WV72 RefSeq (mRNA) NM_145863 NM_001201965 NM_016115 NM_023906 RefSeq (protein) NP_001157637 NP_076395 Location (UCSC) Chr 2: 53.53 – 53.86 Mb Chr 11: 30.84 – 31.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.

External links

• Human ASB3 genome location and ASB3 gene details page in the UCSC Genome Browser.

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
• Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.