ARMCX3

ARMCX3
Identifiers
Aliases	ARMCX3, ALEX3, GASP6, dJ545K15.2, armadillo repeat containing, X-linked 3, armadillo repeat containing X-linked 3
External IDs	OMIM: 300364 MGI: 1918953 HomoloGene: 9588 GeneCards: ARMCX3
Gene location (Human)
Chr.	X chromosome (human)
End	101,627,843 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,662,204 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; spinal ganglia; ; corpus epididymis; ; pons; ; cardia; ; superior vestibular nucleus; ; pylorus; ; inferior ganglion of vagus nerve; ; lactiferous duct; ; body of pancreas;
	Top expressed in
	ovary; ; hippocampus proper; ; neural tube; ; pancreas; ; superior frontal gyrus; ; islet of Langerhans; ; cerebellar cortex; ; mesencephalon; ; lens; ; stomach;
	More reference expression data
	More reference expression data
Orthologs
	51566
	71703
	ENSG00000102401
	ENSMUSG00000049047
	Q9UH62
	Q8BHS6
	NM_016607; NM_177947; NM_177948
	NM_027870; NM_001358520; NM_001358521
NP_057691; NP_808816; NP_808817; NP_057691.1; NP_808816.1;
	NP_808817.1
	NP_082146; NP_001345449; NP_001345450
	Wikidata
View/Edit Human	View/Edit Mouse

Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene.^[5]^[6]^[7]^[8]

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102401 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun. 280 (1): 340–7. doi:10.1006/bbrc.2000.4125. PMID 11162520.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10". J Biol Chem. 284 (20): 13629–40. doi:10.1074/jbc.M901177200. PMC 2679464. PMID 19304657.
^ ^a ^b "Entrez Gene: ARMCX3 armadillo repeat containing, X-linked 3".

External links edit

Human ARMCX3 genome location and ARMCX3 gene details page in the UCSC Genome Browser.

Further reading edit

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102401 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049047 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11162520-5] Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun. 280 (1): 340–7. doi:10.1006/bbrc.2000.4125. PMID 11162520.

[pmid11042152-6] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[pmid19304657-7] Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10". J Biol Chem. 284 (20): 13629–40. doi:10.1074/jbc.M901177200. PMC 2679464. PMID 19304657.

[entrez-8] "Entrez Gene: ARMCX3 armadillo repeat containing, X-linked 3".

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