ARHGEF3

ARHGEF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z0Q
Identifiers
Aliases	ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDs	OMIM: 612115 MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	57,079,329 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	27,125,868 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; endothelial cell; ; Brodmann area 23; ; germinal epithelium; ; middle temporal gyrus; ; oral cavity; ; parietal pleura; ; optic nerve; ; islet of Langerhans;
	Top expressed in
	pontine nuclei; ; cerebellar vermis; ; right lung; ; right lung lobe; ; subiculum; ; olfactory tubercle; ; left lung lobe; ; blood; ; medial vestibular nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure;
Biological process	regulation of Rho protein signal transduction; intracellular signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; positive regulation of apoptotic process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50650
	71704
	ENSG00000163947
	ENSMUSG00000021895
	Q9NR81
	Q91X46
NM_001128615; NM_001128616; NM_001289698; NM_019555; NM_001377407;
	NM_001377408; NM_001377409; NM_001377410; NM_001377411; NM_001377412; NM_001377413; NM_001377414; NM_001377415
	NM_001289686; NM_001289687; NM_001289688; NM_027871
NP_001122087; NP_001122088; NP_001276627; NP_062455; NP_001364336;
	NP_001364337; NP_001364338; NP_001364339; NP_001364340; NP_001364341; NP_001364342; NP_001364343; NP_001364344
	NP_001276615; NP_001276616; NP_001276617; NP_082147
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.^[5]

Function edit

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.^[5]

Interactions edit

ARHGEF3 has been shown to interact with RHOA^[6] and RHOB.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163947 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021895 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
^ ^a ^b Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

External links edit

Human ARHGEF3 genome location and ARHGEF3 gene details page in the UCSC Genome Browser.

Further reading edit

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163947 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021895 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".

[pmid12221096-6] Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

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