ALDH1B1
| Aldehyde dehydrogenase 1 family, member B1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ALDH1B1; ALDH5; ALDHX | ||||||||||||
| External IDs | OMIM: 100670 MGI: 1919785 HomoloGene: 115470 ChEMBL: 4881 GeneCards: ALDH1B1 Gene | ||||||||||||
| EC number | 1.2.1.3 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 219 | 72535 | |||||||||||
| Ensembl | ENSG00000137124 | ENSMUSG00000035561 | |||||||||||
| UniProt | P30837 | Q9CZS1 | |||||||||||
| RefSeq (mRNA) | NM_000692 | NM_028270 | |||||||||||
| RefSeq (protein) | NP_000683 | NP_082546 | |||||||||||
| Location (UCSC) | Chr 9: 38.39 – 38.4 Mb |
Chr 4: 45.8 – 45.8 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene.[1][2]
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems.[2]
Further reading
- Yoshida A (1993). "Molecular genetics of human aldehyde dehydrogenase.". Pharmacogenetics 2 (4): 139–47. doi:10.1097/00008571-199208000-00001. PMID 1306115.
- Hiraoka LR, Hsu L, Hsieh CL (1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13.". Genomics 25 (1): 323–5. doi:10.1016/0888-7543(95)80150-K. PMID 7774944.
- Stewart MJ, Malek K, Xiao Q, et al. (1995). "The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.". Biochem. Biophys. Res. Commun. 211 (1): 144–51. doi:10.1006/bbrc.1995.1789. PMID 7779080.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Sherman D, Davé V, Hsu LC, et al. (1994). "Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.". Hum. Genet. 92 (5): 477–80. doi:10.1007/BF00216454. PMID 8244338.
- Stewart MJ, Malek K, Crabb DW (1996). "Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues.". J. Investig. Med. 44 (2): 42–6. PMID 8689400.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Luo P, Wang A, Payne KJ, et al. (2007). "Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells.". Stem Cells 25 (10): 2628–37. doi:10.1634/stemcells.2007-0264. PMID 17628022.
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