AGH-192

AGH-192
Identifiers
	IUPAC name 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole;
PubChem CID	139488606;
Chemical and physical data
Formula	C13H11FIN3
Molar mass	355.155 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F;
	InChI InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3; Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N;

AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5HT₇ serotonin receptor, derived from the older drug AGH-107. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain.^[1]

References edit

^ Hogendorf AS, Hogendorf A, Popiolek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783. S2CID 85498356.

[1] Hogendorf AS, Hogendorf A, Popiolek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783. S2CID 85498356.

[1]

Identifiers

IUPAC name 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole
PubChem CID	139488606
Chemical and physical data
Formula	C₁₃H₁₁FIN₃
Molar mass	355.155 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F
InChI InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3 Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N

AGH-192

See also edit

References edit