ADCY6

Adenylate cyclase 6
PDB rendering based on 1azs.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1azs, 1cjk, 1cjt, 1cju, 1cjv, 1cs4, 1cul, 1tl7, 1u0h, 2gvd, 2gvz
Identifiers
Symbols	ADCY6; AC6
External IDs	OMIM: 600294 MGI: 87917 HomoloGene: 22400 ChEMBL: 3221 GeneCards: ADCY6 Gene
EC number	4.6.1.1
Gene Ontology Molecular function • adenylate cyclase activity • protein binding • ATP binding • protein kinase binding • metal ion binding Cellular component • plasma membrane • cilium • membrane • integral to membrane Biological process • energy reserve metabolic process • cAMP biosynthetic process • water transport • signal transduction • epidermal growth factor receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • dopamine receptor signaling pathway • synaptic transmission • fibroblast growth factor receptor signaling pathway • activation of protein kinase A activity • intracellular signal transduction • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • transmembrane transport • cellular response to glucagon stimulus • cellular response to prostaglandin E stimulus • cellular response to catecholamine stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	112	11512
Ensembl	ENSG00000174233	ENSMUSG00000022994
UniProt	O43306	Q01341
RefSeq (mRNA)	NM_015270	NM_007405
RefSeq (protein)	NP_056085	NP_031431
Location (UCSC)	Chr 12: 49.16 – 49.18 Mb	Chr 15: 98.59 – 98.61 Mb
PubMed search	[1]	[2]

Adenylate cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.

This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes.". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689. 
• Haber N, Stengel D, Defer N, et al. (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.". Hum. Genet. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Harry A, Chen Y, Magnusson R, et al. (1997). "Differential regulation of adenylyl cyclases by Galphas.". J. Biol. Chem. 272 (30): 19017–21. doi:10.1074/jbc.272.30.19017. PMID 9228084. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Mhaouty-Kodja S, Bouet-Alard R, Limon-Boulez I, et al. (1998). "Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy.". J. Biol. Chem. 272 (49): 31100–6. doi:10.1074/jbc.272.49.31100. PMID 9388262. 
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
• Leech CA, Castonguay MA, Habener JF (1999). "Expression of adenylyl cyclase subtypes in pancreatic beta-cells.". Biochem. Biophys. Res. Commun. 254 (3): 703–6. doi:10.1006/bbrc.1998.9906. PMID 9920805. 
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. 
• Raimundo S, Giray J, Volff JN, et al. (1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.". Clin. Chim. Acta 285 (1-2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931. 
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185. 
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179. 
• Wicker R, Catalan AG, Cailleux A, et al. (2000). "Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.". Biochim. Biophys. Acta 1493 (1-2): 279–83. PMID 10978539. 
• Vanvooren V, Allgeier A, Cosson E, et al. (2001). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid.". Mol. Cell. Endocrinol. 170 (1-2): 185–96. doi:10.1016/S0303-7207(00)00322-1. PMID 11162902. 
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. 
• Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699. 
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.