ACSM2B

Acyl-coenzyme A synthetase ACSM2B, mitochondrial is an enzyme that in humans is encoded by the ACSM2B gene.

ACSM2B
Identifiers
Aliases	ACSM2B, ACSM2, HXMA, HYST1046, acyl-CoA synthetase medium-chain family member 2B, acyl-CoA synthetase medium chain family member 2B
External IDs	OMIM: 614359 MGI: 2385289 HomoloGene: 89289 GeneCards: ACSM2B
Gene location (Human) Chr. Chromosome 16 (human) Band 16p12.3 Start 20,536,226 bp End 20,576,427 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F2 Start 119,153,563 bp End 119,199,913 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney renal cortex sural nerve left uterine tube renal medulla right lobe of thyroid gland body of pancreas left lobe of thyroid gland right adrenal gland Top expressed in proximal tubule kidney morula hair follicle superior frontal gyrus renal corpuscle liver rib quadriceps femoris muscle sphenoid bone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding metal ion binding butyrate-CoA ligase activity CoA-ligase activity fatty-acyl-CoA synthase activity fatty acid ligase activity molecular function Cellular component mitochondrion mitochondrial matrix Biological process xenobiotic metabolic process metabolism fatty acid metabolic process lipid metabolism fatty acid biosynthetic process acyl-CoA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 348158 233799 Ensembl ENSG00000066813 ENSMUSG00000030945 UniProt Q68CK6 Q8K0L3 RefSeq (mRNA) NM_001105069 NM_182617 NM_001177977 NM_001177978 NM_146197 RefSeq (protein) NP_001098539 NP_872423 NP_001171448 NP_001171449 NP_666309 Location (UCSC) Chr 16: 20.54 – 20.58 Mb Chr 7: 119.15 – 119.2 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human ACSM2B genome location and ACSM2B gene details page in the UCSC Genome Browser.

Further reading

• Lindner I, Rubin D, Helwig U, et al. (2006). "The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population". Mol Nutr Food Res. 50 (3): 270–4. doi:10.1002/mnfr.200500241. PMID 16521160.
• Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Vessey DA, Kelley M, Warren RS (2004). "Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver". J. Biochem. Mol. Toxicol. 18 (2): 100–6. doi:10.1002/jbt.20009. PMID 15122652. S2CID 8154380.
• Vessey DA, Kelley M (2001). "Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase". Biochem. J. 357 (Pt 1): 283–8. doi:10.1042/0264-6021:3570283. PMC 1221953. PMID 11415461.
• Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids". Biochim. Biophys. Acta. 1428 (2–3): 455–62. doi:10.1016/s0304-4165(99)00088-4. PMID 10434065.
• Vessey DA, Hu J (1997). "Isolation from bovine liver mitochondria and characterization of three distinct carboxylic acid: CoA ligases with activity toward xenobiotics". J. Biochem. Toxicol. 10 (6): 329–37. doi:10.1002/jbt.2570100608. PMID 8934636.
• Vessey DA, Hu J, Kelley M (1997). "Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria". J. Biochem. Toxicol. 11 (2): 73–8. doi:10.1002/(SICI)1522-7146(1996)11:2<73::AID-JBT4>3.0.CO;2-R. PMID 8884467.