ABCC10

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.

ABCC10
Identifiers
Aliases	ABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10
External IDs	OMIM: 612509 MGI: 2386976 HomoloGene: 58616 GeneCards: ABCC10
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 43,427,366 bp End 43,450,427 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 C Start 46,614,147 bp End 46,639,278 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary right lobe of thyroid gland body of pancreas pylorus endothelial cell pancreatic ductal cell Brodmann area 23 stromal cell of endometrium minor salivary glands Top expressed in substantia nigra trigeminal ganglion yolk sac spermatocyte duodenum proximal tubule ascending aorta secondary oocyte crypt of lieberkuhn of small intestine superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane lysosomal membrane plasma membrane membrane integral component of plasma membrane Biological process transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89845 224814 Ensembl ENSG00000124574 ENSMUSG00000032842 UniProt Q5T3U5 Q8R4P9 RefSeq (mRNA) NM_001198934 NM_033450 NM_001350518 NM_145140 NM_170680 NM_001347396 RefSeq (protein) NP_001185863 NP_258261 NP_001337447 NP_001334325 NP_660122 NP_733780 Location (UCSC) Chr 6: 43.43 – 43.45 Mb Chr 17: 46.61 – 46.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

See also

• ATP-binding cassette transporter

Further reading

• Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily". Cancer Lett. 162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID 11146224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)". Mol. Pharmacol. 63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID 12527806. S2CID 26642179.
• Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991. S2CID 202649323.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404. S2CID 4423608.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465. S2CID 6933602.
• Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis". J. Immunol. 175 (3): 1383–7. doi:10.4049/jimmunol.175.3.1383. PMID 16034073. S2CID 22554947.
• Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines". Int. J. Oncol. 30 (2): 393–401. doi:10.3892/ijo.30.2.393 (inactive 31 January 2024). PMID 17203221.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)

External links

• ABCC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCC10 genome location and ABCC10 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.