This article relies largely or entirely on a single source. (November 2020) |
In enzymology, a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61) is an enzyme that catalyzes the chemical reaction
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 4.2.1.61 | ||||||||
CAS no. | 9030-86-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
- (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hexadec-2-enoyl-[acyl-carrier-protein] + H2O
Hence, this enzyme has one substrate, [[(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein]]], and two products, [[hexadec-2-enoyl-[acyl-carrier-protein]]] and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase (hexadec-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, beta-hydroxypalmitoyl-acyl carrier protein dehydrase, beta-hydroxypalmitoyl thioester dehydratase, beta-hydroxypalmityl-ACP dehydrase, and (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase. This enzyme participates in fatty acid biosynthesis.
Structural studies edit
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFF.
References edit
- Mizugaki M, Swindell AC, Wakil SJ (1968). "Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E coli fatty acid synthetase". Biochem. Biophys. Res. Commun. 33 (3): 520–7. doi:10.1016/0006-291X(68)90607-4. PMID 4881058.