The 2018 San Luis Open Challenger Tour was a professional tennis tournament played on hard courts. It was the 25th edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 27 March and 1 April 2018.
| 2018 San Luis Open Challenger Tour | |
|---|---|
| Date | 27 March – 1 April |
| Edition | 25th |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | San Luis Potosí, Mexico |
| Champions | |
| Singles | |
 Marcelo Arévalo | |
| Doubles | |
Marcelo Arévalo /  Miguel Ángel Reyes-Varela | |
Singles main-draw entrants edit
Seeds edit
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ITA
|
Paolo Lorenzi | 57 | 1 |
 AUT
|
Gerald Melzer | 113 | 2 |
 GER
|
Yannick Hanfmann | 124 | 3 |
 BRA
|
Thomaz Bellucci | 135 | 4 |
 DOM
|
Víctor Estrella Burgos | 152 | 5 |
 USA
|
Evan King | 188 | 6 |
| USA
|
Mitchell Krueger | 207 | 7 |
 SRB
|
Peđa Krstin | 208 | 8 |
- 1 Rankings are as of 19 March 2018.
Other entrants edit
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Champions edit
Singles edit
Marcelo Arévalo def. 
Roberto Cid Subervi 6–3, 6–7(3–7), 6–4.
Doubles edit
- Marcelo Arévalo /
Miguel Ángel Reyes-Varela def. 
Jay Clarke / 
Kevin Krawietz 6–1, 6–4.
