Defending champion Esther Vergeer and her partner Jiske Griffioen defeated the other defending champion Korie Homan and her partner Maaike Smit in the final, 6–4, 6–4 to win the women's doubles wheelchair tennis title at the 2006 US Open.
| Wheelchair women's doubles | |
|---|---|
| 2006 US Open | |
| Champion |  Jiske Griffioen Esther Vergeer |
| Runner-up | Korie Homan Maaike Smit |
| Score | 6–4, 6–4 |
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals edit
| First round | Finals | ||||||||||||
| Jiske Griffioen Esther Vergeer
| 6 | 6 | |||||||||||
 Beth Arnoult Kaitlyn Verfuerth
| 2 | 2 | |||||||||||
| Jiske Griffioen Esther Vergeer
| 6 | 6 | |||||||||||
| Korie Homan Maaike Smit
| 4 | 4 | |||||||||||
| Korie Homan Maaike Smit
| 5 | 6 | 6 | ||||||||||
 Florence Gravellier Sharon Walraven
| 7 | 2 | 4 | ||||||||||