The 1980 season of the African Cup Winners' Cup football club tournament was won by Tout Puissant Mazembe in two-legged final victory against Africa Sports. This was the sixth season that the tournament took place for the winners of each African country's domestic cup. Twenty-eight sides entered the competition, with Dingareh and Ader Club withdrawing before the 1st leg of the first round. No preliminary round took place during this season of the competition.
| Tournament details | |
|---|---|
| Dates | April - 7 December 1980 |
| Teams | 28 (from 1 confederation) |
| Final positions | |
| Champions |  TP Mazembe (1st title) |
| Runners-up |  Africa Sports |
| Tournament statistics | |
| Matches played | 48 |
| Goals scored | 134 (2.79 per match) |
First round edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Africa Sports National
|
w/o |  Dingareh
|
— | — |
Atlético Malabo 
|
3-5 |  US Mbila Nzambi
|
2-2 | 1-3 |
Buffles du Borgou FC 
|
4-7 |  OC Agaza
|
1-2 | 3-5 |
Casa Sport 
|
6-1 |  Bula FC
|
5-1 | 1-0 |
Eleven Wise 
|
4-0 |  Sodiam Sports
|
3-0 | 1-0 |
Espérance 
|
w/o |  Ader Club
|
— | — |
Kadiogo FC 
|
5-5 (4-2 p) |  Wusum Stars
|
4-1 | 1-4 |
KCC 
|
5-2 |  Marine Club FC
|
3-1 | 2-1 |
NA Hussein-Dey 
|
7-1 |  ACS Ksar
|
7-0 | 0-1 |
Matlama FC 
|
5-2 |  Palmeiras de Beira
|
2-0 | 3-2 |
Pan African FC 
|
5-4 |  AS Sotema
|
4-3 | 1-1 |
Township Rollers 
|
3-6 | TP Mazembe
|
2-2 | 1-4 |
Dynamo Douala 
|
bye | |||
Horoya AC 
|
bye | |||
Ramogi United 
|
bye | |||
Shooting Stars F.C. 
|
bye |
Second round edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Africa Sports National
|
abd1 | US Mbila Nzambi
|
3-2 | 1-1 |
| OC Agaza
|
0-0 (2-1 p) | Horoya AC
|
0-0 | 0-0 |
| Casa Sport
|
1-3 | NA Hussein-Dey
|
1-1 | 0-2 |
| Eleven Wise
|
3-2 | Dynamo Douala
|
2-1 | 1-1 |
| Kadiogo FC
|
w/o | Espérance
|
— | — |
| Matlama FC
|
1-1 (a) | Ramogi United
|
1-1 | 0-0 |
| Pan African FC
|
1-2 | Shooting Stars F.C.
|
0-1 | 1-2 |
| TP Mazembe
|
3-2 | KCC
|
1-0 | 2-2 |
- 1:2nd leg abandoned, Africa Sports qualified.
Quarterfinals edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| OC Agaza
|
1-2 | Africa Sports National
|
1-1 | 0-1 |
| Eleven Wise
|
2-5 | NA Hussein-Dey
|
1-1 | 1-4 |
| Ramogi United
|
0-4 | Kadiogo FC
|
0-3 | 0-1 |
| TP Mazembe
|
3-3 (3-0 p) | Shooting Stars F.C.
|
2-1 | 1-2 |
Semifinals edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Africa Sports National
|
3-2 | NA Hussein-Dey
|
1-0 | 2-2 |
| TP Mazembe
|
3-2 | Kadiogo FC
|
1-0 | 2-2 |
Final edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Africa Sports National
|
1-4 | TP Mazembe
|
1-3 | 0-1 |
| African Cup Winners' Cup Winners |
|---|
 Tout Puissant Mazembe First title |