(Butirosin acyl-carrier protein)—L-glutamate ligase (EC 6.2.1.39, [BtrI acyl-carrier protein]—L-glutamate ligase, BtrJ) is an enzyme with systematic name (BtrI acyl-carrier protein):L-glutamate ligase (ADP-forming).[1] This enzyme catalyses the following chemical reaction
| (butirosin acyl-carrier protein)—L-glutamate ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.39 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) ATP + L-glutamate + BtrI acyl-carrier protein ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
- (2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]
This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
References edit
- ^ Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB (June 2005). "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chemistry & Biology. 12 (6): 665–75. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512.
External links edit
- (butirosin+acyl-carrier+protein)—L-glutamate+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
