(Z)-4-Amino-2-butenoic acid
| (Z)-4-Amino-2-butenoic acid[1] | |
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-4-Amino-2-butenoic_acid.png) |
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(Z)-4-Amino-2-butenoic acid |
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Other names
cis-4-Aminocrotonic acid; 4-Amino-cis-2-butenoic acid |
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| Identifiers | |
| Abbreviations | CACA |
| CAS number | 55199-25-2 |
| PubChem | 6603697 |
| ChemSpider | 5036011  |
| ChEMBL | CHEMBL32307 |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C4H7NO2 |
| Molar mass | 101.10 g mol−1 |
| Solubility in water | 124 mg/mL |
| Hazards | |
| S-phrases | S22 S24/25 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA-ρ (previously known as GABAC) subtype.[2][3][4]
References
- ^ cis-4-Aminocrotonic acid at Sigma-Aldrich
- ^ Qian, H; Dowling, JE (1996). "Selective agonists for GABAC receptors". Trends in neurosciences 19 (5): 190. doi:10.1016/0166-2236(96)85451-8. PMID 8723205.
- ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry 75 (6): 2602–10. PMID 11080214.
- ^ Reis, GM; Duarte, ID (2007). "Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid". Life Sciences 80 (14): 1268–73. doi:10.1016/j.lfs.2006.12.015. PMID 17316706.
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