WDR3

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WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.

WDR3
Identifiers
Aliases	WDR3, DIP2, UTP12, WD repeat domain 3
External IDs	OMIM: 604737 MGI: 2443143 HomoloGene: 4937 GeneCards: WDR3
Gene location (Human) Chr. Chromosome 1 (human) Band 1p12 Start 117,929,720 bp End 117,966,543 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 100,045,496 bp End 100,069,723 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell parietal pleura germinal epithelium islet of Langerhans visceral pleura hair follicle tibia ganglionic eminence amniotic fluid endothelial cell Top expressed in primitive streak medullary collecting duct hand condyle fossa superior cervical ganglion abdominal wall renal corpuscle hair follicle substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function snoRNA binding RNA binding Cellular component Pwp2p-containing subcomplex of 90S preribosome small-subunit processome nuclear membrane nucleolus nucleoplasm nucleus Biological process rRNA processing maturation of SSU-rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10885 269470 Ensembl ENSG00000065183 ENSMUSG00000033285 UniProt Q9UNX4 Q8BHB4 RefSeq (mRNA) NM_006784 NM_175552 NM_001355657 RefSeq (protein) NP_006775 NP_780761 NP_001342586 Location (UCSC) Chr 1: 117.93 – 117.97 Mb Chr 3: 100.05 – 100.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

Further reading

• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy". Genomics. 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID 9628821.