David | |
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Personal details | |
Born | wackbuilder September 16, 2022 Brazil |
Political party | Wikipedia Party |
Education | Teahouse University |
Babel user information | ||
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| ||
Users by language |
Hello there! I am Lafo, Welcome to my Wikipedia page.
I'm a fellow user who reads pages most of the times, but sometimes I edit.
If you have anything to say, go to my talk page.
Thanks for reading!
This work is in the public domain because it is exempted by Article 6 of Macao copyright law. This exempts official governmental works and their translations from copyright, and explicitly allows copyrighted free use on any protected work therein. |
I, the copyright holder of this work, hereby release it into the public domain. This applies worldwide. If this is not legally possible: |
Random Crap edit
Laura Moser | |
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Personal details | |
Born | Houston, Texas, U.S. | August 30, 1977
Political party | Democratic |
Education | Amherst College (BA) |
Laura Moser (born August 30, 1977)[1] is an American author and politician who founded the anti-Trump resistance movement Daily Action. She was a candidate for the United States Congress in Texas's 7th congressional district.[2]
This article includes a list of general references, but it lacks sufficient corresponding inline citations. (January 2022) |
2010 World Junior Wrestling Championships | |
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Host city | Budapest, Hungary |
Dates | 19–25 July 2010 |
Champions | |
Freestyle | Russia |
Greco-Roman | Russia |
Women | Russia |
The 2010 World Junior Wrestling Championships were the 33rd edition of the World Junior Wrestling Championships and were held in Budapest, Hungary between 19 and 25 July 2010.[3][4][5][6][7][8][9][10]
Clinical data | |
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Trade names | Belsomra |
Other names | MK-4305; MK4305 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a614046 |
License data |
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Pregnancy category | |
Dependence liability | Low |
Addiction liability | Low |
Routes of administration | By mouth[12] |
Drug class | Orexin receptor antagonist; Hypnotic; Sedative |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 82% (10 mg; lower at higher doses)[12][16] |
Protein binding | 99.5%[17][12] |
Metabolism | Liver (CYP3A major, CYP2C19 minor)[12] |
Metabolites | Hydroxysuvorexant (inactive)[12] |
Elimination half-life | 12.2 hours (8–19 hours) (40 mg)[12][16][18] |
Excretion | Feces: 66%[12] Urine: 23%[12] |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
Chemical and physical data | |
Formula | C23H23ClN6O2 |
Molar mass | 450.93 g·mol−1 |
3D model (JSmol) | |
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(verify) |
Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia.[12][17] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset and/or maintenance in adults.[12][17] Suvorexant helps with falling asleep faster, sleeping longer, being awake less in the middle of the night, and having better quality of sleep.[12][19] Its effectiveness is modest,[20] and is similar to that of other orexin antagonists, but is lower than that of benzodiazepines and Z-drugs.[21] Suvorexant is taken by mouth.[12][22][17]
Side effects of suvorexant include somnolence, daytime sleepiness and sedation, headache, dizziness, abnormal dreams, dry mouth, and impaired next-day driving ability.[12][19][23] Rarely, sleep paralysis, sleep-related hallucinations, complex sleep behaviors like sleepwalking, and suicidal ideation may occur.[12][17][20] Tolerance, dependence, withdrawal, and rebound effects do not appear to occur significantly with the medication.[12][24][25] Suvorexant is a dual orexin receptor antagonist (DORA).[17] It acts as a selective dual antagonist of the orexin OX1 and OX2 receptors.[17] The medication has an intermediate elimination half-life of 12 hours and a time to peak of about 2 to 3 hours.[12][17] Unlike benzodiazepines and Z-drugs, suvorexant does not interact with GABA receptors, instead having a distinct mechanism of action.[17][26]
Clinical development of suvorexant began in 2006[27] and it was introduced for medical use in 2014.[12][28] The medication is a schedule IV controlled substance in the United States and may have a modest potential for misuse.[29][12][30] In other places, such as Australia, suvorexant is a prescription-only medicine and is not a controlled drug.[11] Suvorexant is not available in generic formulations.[22][31][32] Besides suvorexant, other orexin receptor antagonists like lemborexant and daridorexant have also been introduced.[33][34]
Billy Preston & Syreeta | |
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Studio album by | |
Released | 1981 |
Studio | Motown/Hitsville U.S.A. Recording Studios (Los Angeles, California)
|
Genre | R&B, Soul |
Label | Motown |
Producer |
|
Billy Preston & Syreeta is a 1981 album of duets by Billy Preston and Syreeta released by Motown Records.[35] Six songs were produced by Ollie Brown, and four songs were produced and co-written by Michael Masser. An expanded version of the album with 10 songs and 7 bonus cuts was released on CD in late 2013 on SoulMusic Records.[36]
Shire of Gayndah Queensland | |||||||||||||||
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Population | 2,911 (2006 census)[37] | ||||||||||||||
• Density | 1.07445/km2 (2.7828/sq mi) | ||||||||||||||
Established | 1866 | ||||||||||||||
Area | 2,709.3 km2 (1,046.1 sq mi) | ||||||||||||||
Council seat | Gayndah | ||||||||||||||
Region | Wide Bay–Burnett | ||||||||||||||
Website | Shire of Gayndah | ||||||||||||||
|
The Shire of Gayndah was a local government area located in the northern catchment of the Burnett River, Queensland, Australia. The shire covered an area of 2,709.3 square kilometres (1,046.1 sq mi), and existed as a local government area from 1866 until 2008, when it amalgamated with several other shires to form the North Burnett Region.
Major activities in the shire included citrus production, beef and timber.
Wackbuilder edit
Joseph Elias Wack | |
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Personal details | |
Born | José Elias Vaque da Silva May 14, 2001 Rio de Janeiro, Rio de Janeiro (state), Brazil |
Died | November 28, 2022 London, UK | (aged 21)
Education | Wikimedia University |
Joseph Elias Wack (May 14, 2001 - November 28, 2022) was a Brazilian author known for his online stories. Wack was shot dead while in London by "Spacebuilder" because he had exposed Spacebuilder as a pedophile.
- ^ "Jewish Women's Archive. "Laura Moser"". Retrieved 17 June 2017.
- ^ Diaz, Kevin (3 May 2017). "In the age of Trump, Democrats zero in on a longtime GOP House seat". Houston Chronicle. Retrieved 26 June 2017.
- ^ "International Wrestling Database".
- ^ "International Wrestling Database".
- ^ "International Wrestling Database".
- ^ "International Wrestling Database".
- ^ "International Wrestling Database".
- ^ "International Wrestling Database".
- ^ "Azerbaijan Greco-Roman Wrestling Team Ranks Second in World Championship".
- ^ "2010 Junior World Wrestling Championships".
- ^ a b Cite error: The named reference
Belsomra-AU-Label
was invoked but never defined (see the help page). - ^ a b c d e f g h i j k l m n o p q r s t "Belsomra- suvorexant tablet, film coated". DailyMed. Retrieved 30 January 2020.
- ^ Cite error: The named reference
Drugs.com-Pregnancy
was invoked but never defined (see the help page). - ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
- ^ "Search Page - Drug and Health Product Register". 23 October 2014.
- ^ a b Cite error: The named reference
MerckSharpDohme2013
was invoked but never defined (see the help page). - ^ a b c d e f g h i Jacobson LH, Callander GE, Hoyer D (November 2014). "Suvorexant for the treatment of insomnia". Expert Review of Clinical Pharmacology. 7 (6): 711–730. doi:10.1586/17512433.2014.966813. PMID 25318834. S2CID 41099462.
- ^ Cite error: The named reference
DimovaBrarMen2014
was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
pmid28365447
was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
pmid26648692
was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid35843245
was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
Drugs.com-Belsomra-Generic
was invoked but never defined (see the help page). - ^ Kishi T, Matsunaga S, Iwata N (2015). "Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials". PLOS ONE. 10 (8): e0136910. Bibcode:2015PLoSO..1036910K. doi:10.1371/journal.pone.0136910. PMC 4552781. PMID 26317363.
- ^ Cite error: The named reference
pmid28994603
was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid32901578
was invoked but never defined (see the help page). - ^ Atkin T, Comai S, Gobbi G (April 2018). "Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery". Pharmacological Reviews. 70 (2): 197–245. doi:10.1124/pr.117.014381. PMID 29487083. S2CID 3578916.
- ^ Cite error: The named reference
pmid25406050
was invoked but never defined (see the help page). - ^ Cite error: The named reference
APDNews2014
was invoked but never defined (see the help page). - ^ Cite error: The named reference
FederalRegister2016
was invoked but never defined (see the help page). - ^ Cite error: The named reference
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was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid30092886
was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid26955275
was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid35043499
was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid35298826
was invoked but never defined (see the help page). - ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta, LP 1981
- ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta (Expanded CD Edition)
- ^ Australian Bureau of Statistics (25 October 2007). "Gayndah (S) (Local Government Area)". 2006 Census QuickStats. Retrieved 18 March 2008.