Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[5]

TNS1
Identifiers
AliasesTNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDsOMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308022
NM_001308023
NM_022648

NM_001289895
NM_027884
NM_177169

RefSeq (protein)

NP_001294951
NP_001294952
NP_072174
NP_001294951.1
NP_001294952.1

n/a

Location (UCSC)Chr 2: 217.8 – 218 MbChr 1: 73.95 – 74.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079308Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055322Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNS1 tensin 1".
edit

Further reading

edit