Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.[5][6] RAP2B belongs to the Ras-related protein family.

RAP2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAP2B, member of RAS oncogene family
External IDsOMIM: 179541; MGI: 1921262; HomoloGene: 55701; GeneCards: RAP2B; OMA:RAP2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002886

NM_028712

RefSeq (protein)

NP_002877

NP_082988

Location (UCSC)Chr 3: 153.16 – 153.17 MbChr 3: 61.27 – 61.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181467Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036894Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG (Oct 1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A. 87 (17): 6527–31. Bibcode:1990PNAS...87.6527O. doi:10.1073/pnas.87.17.6527. PMC 54569. PMID 2118648.
  6. ^ a b "Entrez Gene: RAP2B RAP2B, member of RAS oncogene family".

Further reading

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