Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.[5][6][7]

ARAP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDsOMIM: 606647; MGI: 2147274; HomoloGene: 11199; GeneCards: ARAP3; OMA:ARAP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022481

NM_001205336
NM_139206

RefSeq (protein)

NP_071926

NP_001192265
NP_631945

Location (UCSC)Chr 5: 141.65 – 141.68 MbChr 18: 38.11 – 38.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120318Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024451Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
  6. ^ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. Bibcode:2002CBio...12.R360S. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. S2CID 15875666.
  7. ^ a b "Entrez Gene: CENTD3 centaurin, delta 3".
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Further reading

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