Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[5][6][7][8]

AFAP1
Identifiers
AliasesAFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDsOMIM: 608252; MGI: 1917542; HomoloGene: 11009; GeneCards: AFAP1; OMA:AFAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134647
NM_021638
NM_198595
NM_001371090
NM_001371091

NM_027373

RefSeq (protein)

NP_001128119
NP_940997
NP_001358019
NP_001358020

NP_081649
NP_001390348
NP_001390349
NP_001390350

Location (UCSC)Chr 4: 7.76 – 7.94 MbChr 5: 36.05 – 36.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196526Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029094Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. S2CID 38130241.
  6. ^ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. S2CID 21926408.
  7. ^ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
  8. ^ a b "Entrez Gene: AFAP1 actin filament associated protein 1".
edit

Further reading

edit