User:Valentina Martinez Mafla/sandbox

Valentina Martinez Mafla/sandbox
Clinical data
Trade namesClaritin, Claratyne, Clarityn, others
AHFS/Drugs.comMonograph
MedlinePlusa697038
License data
Pregnancy
category
Routes of
administration
By mouth
Drug classSecond-generation antihistamine
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilityalmost 100%
Protein binding97–99%
Metabolismliver (CYP2D6- and 3A4-mediated)
Elimination half-life8 hours, active metabolite desloratadine 27 hours
Excretion40% as conjugated metabolites into urine
Similar amount into the feces
Identifiers
  • Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC22H23ClN2O2
Molar mass382.89 g·mol−1
3D model (JSmol)
  • O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4
  • InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 checkY
  • Key:JCCNYMKQOSZNPW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
  1. ^ "Loratadine Use During Pregnancy". Drugs.com. 10 February 2020. Retrieved 10 April 2020.
  2. ^ "Claritin Allergy Product information". Health Canada. 25 April 2012. Retrieved 7 June 2022.
  3. ^ "Clarityn Allergy 10mg Tablets (P & GSL) - Patient Information Leaflet (PIL)". (emc). 30 August 2019. Archived from the original on 10 April 2020. Retrieved 10 April 2020.