Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.[5][6]

GTF3A
Identifiers
AliasesGTF3A, AP2, TFIIIA, general transcription factor IIIA
External IDsOMIM: 600860; MGI: 1913846; HomoloGene: 55630; GeneCards: GTF3A; OMA:GTF3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002097

NM_025652

RefSeq (protein)

NP_002088

NP_079928

Location (UCSC)Chr 13: 27.42 – 27.44 MbChr 5: 146.89 – 146.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It was first purified and identified as the first mammalian gene-specific activator by Roeder in 1980,[7] and later characterized by Wolffe and Brown in 1988.

The TFIIIA in Xenopus was the first zinc finger protein discovered.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122034Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016503Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.
  6. ^ "Entrez Gene: GTF3A general transcription factor IIIA".
  7. ^ Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes". Cell. 19 (3): 717–28. doi:10.1016/S0092-8674(80)80048-1. PMID 6153931. S2CID 23955175.
  8. ^ Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. 53 (1). Annual Reviews: 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518. S2CID 202572327.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.