Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.[5][6][7]

SGPL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSGPL1, S1PL, SPL, sphingosine-1-phosphate lyase 1, NPHS14
External IDsOMIM: 603729; MGI: 1261415; HomoloGene: 2897; GeneCards: SGPL1; OMA:SGPL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003901

NM_009163
NM_001316673
NM_001316674

RefSeq (protein)

NP_003892

NP_001303602
NP_001303603
NP_033189

Location (UCSC)Chr 10: 70.82 – 70.88 MbChr 10: 60.93 – 60.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166224Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020097Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
  6. ^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. Bibcode:2006PNAS..10317384O. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
  7. ^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

Further reading

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