Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[5][6]

SPIB
Identifiers
AliasesSPIB, SPI-B, Spi-B transcription factor
External IDsOMIM: 606802; MGI: 892986; HomoloGene: 79220; GeneCards: SPIB; OMA:SPIB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003121
NM_001243998
NM_001243999
NM_001244000

NM_019866

RefSeq (protein)

NP_001230927
NP_001230928
NP_001230929
NP_003112

NP_063919

Location (UCSC)Chr 19: 50.42 – 50.43 MbChr 7: 44.18 – 44.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][6]

Interactions

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SPIB has been shown to interact with MAPK3[7] and MAPK8.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000269404Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008193Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology. 12 (10): 4297–304. doi:10.1128/mcb.12.10.4297. PMC 360353. PMID 1406622.
  6. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".
  7. ^ a b Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene. 12 (4): 863–73. PMID 8632909.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.