Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.[5]

NEMF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNEMF, NY-CO-1, SDCCAG1, nuclear export mediator factor, IDDSAPN
External IDsOMIM: 608378; MGI: 1918305; HomoloGene: 3458; GeneCards: NEMF; OMA:NEMF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301732
NM_004713

NM_025441
NM_181665

RefSeq (protein)

NP_001288661
NP_004704

NP_079717

Location (UCSC)Chr 14: 49.78 – 49.85 MbChr 12: 69.36 – 69.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a component of the ribosome quality control complex.[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165525Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020982Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nuclear export mediator factor".
  6. ^ Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.