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Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Cromolyn.svg/220px-Cromolyn.svg.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/12/Nedocromil.svg/220px-Nedocromil.svg.png)
As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis.[2] Finally, in oral form, they are used to treat the rare condition of mastocytosis.
Examples
editMast cell stabilizer medications include:
- Cromoglicic acid[1][3][4][5] (Cromolyn/cromoglycate)
- Lodoxamide[1][3]
- Nedocromil[1][3][4]
References
edit- ^ a b c d "Allergy medications: Know your options". Mayoclinic.com. 2022-03-05. Retrieved 2023-04-02.
- ^ Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane Database Syst Rev. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608.
- ^ a b c d e f g h "Mast Cell Stabilizers: Uses, most common brand names, and safety information". nicerx.com. Retrieved 2023-04-02.
- ^ a b "Mast cell stabilizers". drugs.com. Retrieved 2023-04-02.
- ^ Finn, D F; Walsh, J J (2013-08-15). "Twenty-first century mast cell stabilizers". British Journal of Pharmacology. 170 (1): 23–37. doi:10.1111/bph.12138. PMC 3764846. PMID 23441583.
- ^ Lui, ZQ; Lii, XX; Qui, ZQ; Yu, Y; Li, MG (2017). "Vitamin D contributes to mast cell stabilization". Allergy. 72 (8): 1184–1192. doi:10.1111/all.13110. PMID 27998003. S2CID 4643742.