Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.[5][6]

KIF2C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF2C, CT139, KNSL6, MCAK, kinesin family member 2C
External IDsOMIM: 604538; MGI: 1921054; HomoloGene: 21355; GeneCards: KIF2C; OMA:KIF2C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297655
NM_001297656
NM_001297657
NM_006845

NM_001290662
NM_134471

RefSeq (protein)

NP_001284584
NP_001284585
NP_001284586
NP_006836

NP_001277591
NP_608301

Location (UCSC)Chr 1: 44.74 – 44.77 MbChr 4: 117.02 – 117.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.[7] Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.[6]

A ribbon and surface diagram of the KIF2C motor domain.[8] The kinesin structure is pseudo-colored to highlight the ATPase site with a bound nucleotide. The figure then presents KIF2C binding to the tubulin dimer and finally visualizes a KIF2C motor head in the context of the microtubule filament.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142945Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028678Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim IG, Jun DY, Sohn U, Kim YH (December 1997). "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1359 (3): 181–186. doi:10.1016/s0167-4889(97)00103-1. PMID 9434124.
  6. ^ a b "Entrez Gene: KIF2C kinesin family member 2C".
  7. ^ Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B (July 2017). "Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin". Nature Communications. 8 (1): 70. doi:10.1038/s41467-017-00091-9. PMC 5503940. PMID 28694425.
  8. ^ "RCSB PDB - 3EDL: Kinesin13-Microtubule Ring complex". RCSB Protein Data Bank. Retrieved 2024-04-21.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q99661 (Kinesin-like protein KIF2C) at the PDBe-KB.