Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.[2]

Endonuclease/Exonuclease/phosphatase family
Structure of the multifunctional DNA-repair enzyme exonuclease III.[1]
Identifiers
SymbolExo_endo_phos
PfamPF03372
InterProIPR005135
PROSITEPDOC00598
SCOP21ako / SCOPe / SUPFAM
OPM superfamily139
OPM protein1zwx
CDDcd08372
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Examples

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Subfamilies

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Human proteins containing this domain

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2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP; Nocturnin;

Notes

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  1. ^ Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.
  2. ^ Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
  3. ^ Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A (May 2019). "The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)". Nature Communications. 10 (1): 2367. doi:10.1038/s41467-019-10125-z. PMC 6542800. PMID 31147539.

References

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