ZZ-type zinc finger-containing protein 3 is a protein that in humans is encoded by the ZZZ3 gene.[5]

ZZZ3
Protein ZZZ3 PDB 2FC7.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZZZ3, ATAC1, zinc finger ZZ-type containing 3
External IDsMGI: 1920453 HomoloGene: 9182 GeneCards: ZZZ3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308237
NM_015534

NM_001080755
NM_001287139
NM_198416
NM_001346655
NM_001355673

RefSeq (protein)

NP_001074224
NP_001274068
NP_001333584
NP_001342602

Location (UCSC)Chr 1: 77.56 – 77.68 MbChr 3: 152.4 – 152.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organismsEdit

Model organisms have been used in the study of ZZZ3 function. A conditional knockout mouse line, called Zzz3tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[7] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abnormal phenotypes were identified.[7]

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000036549 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039068 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: zinc finger, ZZ-type containing 3". Retrieved 2011-08-30.
  6. ^ "Citrobacter infection data for Zzz3". Wellcome Trust Sanger Institute.
  7. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium".
  10. ^ "Mouse Genome Informatics".
  11. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  12. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further readingEdit