William Simonton was born in West Hanover Township, Pennsylvania, near Harrisburg, Pennsylvania, to Dr. William Simonton and Jane Wiggins. He graduated from the medical department of the University of Pennsylvania at Philadelphia in 1810 and practiced his profession while residing on his farm near Hummelstown, Pennsylvania. Simonton was elected auditor of Dauphin County, Pennsylvania, in 1823 and served three years. He was one of the original supporters of the free-school system established by the act of 1834.
Simonton was elected as a Whig to the Twenty-sixth and Twenty-seventh Congresses. He died in South Hanover Township, Pennsylvania, in 1846. Interment in the Old Hanover Cemetery, north of Shellsville, Pennsylvania.
- United States Congress. "William Simonton (id: S000427)". Biographical Directory of the United States Congress.
- The Political Graveyard
- "American Historical Company. History of Pittsburgh and Environs, Volume 1. The American Historical Society, Inc. New York and Chicago, 1922. pg. 119