Daughter of historian prof. Petar Mutafchiev and Nadia Triphonova, she was born in Sofia and was educated at Sofia University. Vera Mutafchieva obtained her PhD (1958) and DSci (1978) degrees at the Bulgarian Academy of Sciences (BAS) in Sofia. She was a senior researcher at various institutes of the BAS (Institute of History; Institute of Balkan Studies; Institute of Demographic Studies; Institute of Literature), and was elected vice-president of BAS (1993-1996). In 2004 she was elected a member of the Bulgarian Academy of Sciences. Her research focused on the Ottoman period on which she published dozens of studies in Bulgarian and European journals. Some of her monographies were published in the USA, Turkey and Greece.  
Vera Mutafchieva is the author of historical novels which were translated into 11 languages. She was also script writer of the 1981 film Khan Asparuh (4th position in the Most Viewed Movies in Bulgaria of All Times Chart and Official submission of Bulgaria for the 'Best Foreign Language Film' category of the 55th Academy Awards in 1983 ; international title 681 AD: The Glory of Khan ) and of 2 other films on contemporary subjects, as well as of the drama on the second Bulgarian Kingdom "The Road".
Vera Mutafchieva was awarded with numerous national prizes and with the International Herder Prize (1980).
From 1997 to 1998, Mutafchieva was head of the State Agency for Bulgarians Abroad. In 2008, it was revealed that she had collaborated with the secret police in communist Bulgaria. However, she is also known for her defence of women's rights in Bulgaria.
- Detrez, Raymond (2014). Historical Dictionary of Bulgaria. p. 339. ISBN 1442241802.
- Sleeman, Elizabeth (2001). The International Who's Who of Women 2002. p. 395. ISBN 1857431227.
- Mutafchieva, Vera P. (1988). Agrarian Relations in the Ottoman Empire in the 15th and 16th Centuries. ISBN 0880331488.
- Moutaftchieva, Vera (1990). Αγροτικές σχέσεις στην Οθωμανική αυτοκρατορία (15ος - 16ος αι.) (Agrotikes Scheseis stin Othomaniki Avtokratoria (15os – 16os ai)). ISBN 960-7043-01-4.
- Moutaftchieva, Vera (2005). L'anarchie dans les Balkans a la fin du XVIIIe siècle. ISBN 975-428-295-1.
- "Official site of Vera Mutafchieva".
- "Renown Bulgarian Historian, Writer Vera Mutafchieva Dies at 80". novinite.com. June 9, 2009.
- "Aszparuh (1981) Trivia".
- "681 AD: The Glory of Khan".
- "Vera Mutafchieva (1929–2009), Writer, at IMDb".