Venomous snakes are species of the suborder Serpentes that are capable of producing venom, which they use for killing prey, for defense, and to assist with digestion of their prey. The venom is typically delivered by injection using hollow or grooved fangs, although some venomous snakes lack well-developed fangs. Common venomous snakes include the families Elapidae, Viperidae, Atractaspididae, and some of the Colubridae. The toxicity of venom is mainly indicated by murine LD50, while multiple factors are considered to judge the potential danger to humans. Other important factors for risk assessment include the likelihood that a snake will bite, the quantity of venom delivered with the bite, the efficiency of the delivery mechanism, and the location of a bite on the body of the victim. Snake venom may have both neurotoxic and hemotoxic properties.
The evolutionary history of venomous snakes can be traced back to as far as 25 million years ago. Snake venom is actually modified saliva used for prey immobilization and self-defense and is usually delivered through highly specialized teeth, hollow fangs, directly into the bloodstream or tissue of the target. Evidence has recently been presented for the toxicofera hypothesis, but venom was present (in small amounts) in the ancestors of all snakes (as well as several lizard families) as "toxic saliva" and evolved to extremes in those snake families normally classified as venomous by parallel evolution. The toxicofera hypothesis further implies[according to whom?] that "nonvenomous" snake lineages have either lost the ability to produce venom (but may still have lingering venom pseudogenes), or actually do produce venom in small quantities, likely sufficient[according to whom?] to help capture small prey but causing no harm to humans when bitten.
There is not a single or special taxonomic group for venomous snakes that comprise species from different families. This has been interpreted[by whom?] to mean venom in snakes originated more than once as the result of convergent evolution. Around a quarter of all snake species are identified as being venomous.[according to whom?]
|Atractaspididae (atractaspidids)||Burrowing asps, mole vipers, stiletto snakes|
|Colubridae (colubrids)||Most are harmless, but others have potent venom and at least five species, including the boomslang (Dispholidus typus), have caused human fatalities.|
|Elapidae (elapids)||Sea snakes, taipans, brown snakes, coral snakes, kraits, death adders, tiger snakes, mambas, king cobra and cobras|
|Viperidae (viperids)||True vipers, including the Russell's viper, saw-scaled vipers, puff adders and pit vipers, including rattlesnakes, lanceheads and copperheads and cottonmouths.|
Venomous snakes are often said to be poisonous, but poison and venom are not the same thing. Poisons must be ingested, inhaled or absorbed, while venom must be injected into the body by mechanical means. While unusual, there are a few species of snake which are actually poisonous. Rhabdophis keelback snakes are both venomous and poisonous – their poisons are stored in nuchal glands and are acquired by sequestering toxins from poisonous toads the snakes eat. Similarly, certain garter snakes from Oregon can retain toxins in their livers from ingesting rough-skinned newts.
Venom toxicities are compared by looking at the median lethal dose (usually using rodents as test animals and termed the murine LD50), which is the dose of venom per unit body mass that kills half of the test animals that receive it. The result obtained depends on which of the four delivery sites is used for the injection: subcutis (SC), vein (IV), muscle (IM or IC), or peritoneum (IP). Smaller murine LD50 values indicate venoms that are more toxic, and there have been numerous studies on snake venom with a variability of potency estimates. SC LD50 is considered[by whom?] the most applicable to actual bites as only vipers with large fangs (such as large specimens from the genera Bitis, Bothrops, Crotalus, or Daboia) are capable of a truly intramuscular bite, snakebites rarely cause IV envenomation, and IP envenomation is even rarer. Measurements of LD50 using dry venom mixed with 0.1% bovine serum albumin in saline are more consistent than the results obtained using saline alone. As an example, the venom of the eastern brown snake has a murine LD50 (SC) of 41 μg/kg when measured in 0.1% bovine serum albumin in saline; when saline alone is used, the value is 53 μg/kg.
Belcher's sea snake (Hydrophis belcheri), which sometimes is mistakenly called the hook-nosed Sea Snake (Enhydrina schistosa), has been erroneously popularized[according to whom?] as the most venomous snake in the world, due to the first edition of Ernst and Zug's book, Snakes in Question: The Smithsonian Answer Book, published in 1996. Prominent venom expert Associate Professor Bryan Grieg Fry has clarified the error: "The hook nosed myth was due to a fundamental error in a book called Snakes in Question. In there, all the toxicity testing results were lumped in together, regardless of the mode of testing (e.g., subcutaneous vs. intramuscular vs. intravenous vs. intraperitoneal). As the mode can influence the relative number, venoms can only be compared within a mode. Otherwise, it's apples and rocks." Belcher's sea snake's actual LD50 (IM) is 0.24 mg/kg and 0.155 mg/kg. Studies on mice and human cardiac cell culture show that venom of the inland taipan, drop by drop, is the most toxic among all snakes.
|Snake||Region||subcutaneous injection LD50||intravenous injection LD50|
|0.1% bovine serum albumin in Saline||in saline|
|Inland taipan||Australia||0.01 mg/kg||0.025 mg/kg||N/A|
|Dubois' sea snake||Coral Sea, Arafura Sea, Timor Sea, Tar River, and Indian Ocean||N/A||0.044 mg/kg||N/A|
|Eastern brown snake||Australia, Papua New Guinea, Indonesia||0.041 mg/kg||0.053 mg/kg||0.01 mg/kg|
|Yellow bellied sea snake||Tropical oceanic waters||N/A||0.067 mg/kg||N/A|
|Peron's sea snake||Gulf of Siam, Strait of Taiwan, Coral sea islands, and other places||N/A||0.079 mg/kg||N/A|
|Coastal taipan||Australia||0.064 mg/kg||0.105 mg/kg||0.013 mg/kg|
|Many-banded krait||Mainland China, Taiwan, Vietnam, Laos, Burma||N/A||0.108 mg/kg||0.061 mg/kg|
|Black-banded sea krait||eastern coast of the Malay Peninsula and Brunei, and in Halmahera, Indonesia..||N/A||0.111 mg/kg||N/A|
|Black Tiger snake||Australia||0.099 mg/kg||0.131 mg/kg||N/A|
|Mainland Tiger snake||Australia||0.118 mg/kg||0.118 mg/kg||0.014 mg/kg|
|Western Australian Tiger snake||Australia||0.124 mg/kg||0.194 mg/kg||N/A|
|Beaked sea snake||Tropical Indo-Pacific||0.164 mg/kg||0.1125 mg/kg||N/A|
The toxicity of snake venom (based on laboratory tests conducted on mice) is sometimes used to gauge the extent of danger to humans, but this is not enough. Many venomous snakes are specialized predators whose venom may be adapted specifically to incapacitate their preferred prey. A number of other factors are also critical in determining the potential hazard of any given venomous snake to humans, including their distribution and behavior. For example, while the inland taipan is regarded as the world's most venomous snake based on LD50 tests on mice, it is a shy species and rarely strikes, and has not caused any known human fatalities. On the other hand, India's Big Four (Indian cobra, common krait, Russell's viper, and saw-scaled viper), while less venomous than the inland taipan, are found in closer proximity to human settlements and are more confrontational, thus leading to more deaths from snakebite. In addition, some species, such as the black mamba and coastal taipan, occasionally show some aggression, generally when alarmed or in self-defence, and then may deliver fatal doses of venom, resulting in high human mortality rates.
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- Mackessy, Stephen P. (June 2002). "Biochemistry and pharmacology of colubrid snake venoms" (PDF). Journal of Toxicology: Toxin Reviews. 21 (1–2): 43–83. CiteSeerX 10.1.1.596.5081. doi:10.1081/TXR-120004741. Archived from the original (PDF) on 2010-06-02. Retrieved 2009-09-26.
- Broad, A. J.; Sutherland, S. K.; Coulter, A. R. (1979). "The lethality in mice of dangerous Australian and other snake venom" (PDF). Toxicon. 17 (6): 661–664. doi:10.1016/0041-0101(79)90245-9. PMID 524395.
- Fry, Bryan Archived 2014-04-19 at the Wayback Machine (February 08, 2005) Most Venomous Archived 2014-10-17 at the Wayback Machine,"Q;I was wondering what snakes venom is the most potent to humans A:Drop for drop it is the inland taipan (Oxyuranus microlepidotus), which has a venom more toxic than any other land snake or even the sea snakes." venomdoc.com Forums, Retrieved April 17, 2014
- Tamiya, N.; Puffer, H. (1974). "Lethality of sea snake venoms". Toxicon. 12 (1): 85–87. doi:10.1016/0041-0101(74)90104-4. PMID 4818649.
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- "Which snakes are the most venomous?". Australian Venom Research Unit, University of Melbourne. August 25, 2007. Archived from the original on June 26, 2014. Retrieved October 14, 2013.
- "Frequently Asked Questions: What is the most venomous snake?". Venom Immunochemistry, Pharmacology and Emergency Response (VIPER) Institute, University of Arizona. Retrieved October 14, 2013.
Many experts answer that it is the Inland Taipan of Australia, because its drop-by-drop concentration of venom has great potency when measured by its ability to kill rodents.
- Florida Department of Wildlife Ecology and Conservation. "Frequently Asked Questions About Venomous Snakes". University of Florida. Retrieved November 5, 2013.
A comparative study found that the snake venom that is most toxic to mice (of the species tested) is that of the Inland Taipan (Oxyuranus microlepidotus), found in Australia
- Hodgson, W. C.; Dal Belo, C. A.; Rowan, E. G. (2007). "The neuromuscular activity of paradoxin: A presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)". Neuropharmacology. 52 (5): 1229–1236. doi:10.1016/j.neuropharm.2007.01.002. PMID 17313963.
The inland taipan is the world's most venomous snake
- Bell, Karen L.; Sutherland, Struan K.; Hodgson, Wayne C. (1998). "Some pharmacological studies of venom from the inland taipan (Oxyuranus microlepidotus)". Toxicon. 36 (1): 63–74. doi:10.1016/S0041-0101(97)00060-3. PMID 9604283.
The Inland Taipan is believed to have the most toxic venom in the world (Sutherland, 1994)
- Shine, Richard; Covacevich, Jeanette (1983). "Ecology of Highly Venomous Snakes: the Australian Genus Oxyuranus (Elapidae)" (PDF). Journal of Herpetology. 17 (1): 60–69. doi:10.2307/1563782.
... the number of mouse LD50 doses per bite is much higher for Oxyuranus microlepidotus (218,000 mice) ... than for any other snakes, including sea snakes, investigated to date (Broad, Sutherland and Coulter, 1979).
- LISTS . Nine of the World's Deadliest Snakes. "#1: The snake with the world's deadliest venom - Oxyuranus microlepidotus" . Encyclopædia Britannica. Retrieved November 5, 2013.
- BBC Nature Wildlife. Inland Taipan page. "Australia's inland taipan is considered to be the most venomous snake in the world". BBC. Retrieved October 15, 2013.
- Cecilie Beatson (November 29, 2011). Animal Species: Inland Taipan "The venom of the Inland Taipan is extremely potent and is rated as the most toxic of all snake venoms in LD50 tests on mice". Australian Museum. Retrieved October 14, 2013.
- Steve Irwin presentation .Australia Zoo Tour with Steve Irwin (1m54s) "..the number 1 most venomous snake in the entire world, the fierce snake". Australia Zoo (official Youtube Channel). Retrieved October 14, 2013.
- Inland Taipan Venom vs. Sea Snakes Venom (most notable Belcher's sea snake)
- Oakley, Cecily (2011). Interview with Associate Professor Bryan Fry Biochemist and molecular biologist Archived 2013-10-22 at the Wayback Machine. "...For my PhD, I worked on the inland taipan, which is the world’s most venomous snake..." . Australian Academy of Science. Retrieved October 14, 2013.
- kingsnake.com September Guest Chatter (September 16, 2006).Q&A with Dr. Bryan Grieg Fry, Deputy Director, Australian Venom Research Unit, University of Melbourne Archived 2012-10-15 at the Wayback Machine. "Q: In retrospect to the LD50 charts, what do you personally feel is the hottest snake, in regards to potency, defensiveness, means of injection, etc.? A: It is the inland taipan (Oxyuranus microlepidotus). Not, as is popularised, any of the sea snakes." connectedbypets.com. Retrieved October 14, 2013.
- Garden of Eden Exotics (May 2, 2012) Dr. Bryan Grieg Fry – Interview "...The inland taipan (Oxyuranus microlepidotus') is far and away the most toxic, much more so than even sea snakes." nyexotics.blogspot.com Retrieved October 14, 2013
- Seymour, Jamie. "World's Worst Venom". National Geographic Channel. Retrieved April 17, 2014.
(starting at 44 min 33 s): "Among the reptiles tested, the most toxic venom belongs to inland taipan, killing over 60% of heart cells in the first 10 minutes
- Seymour, Jamie. "Venom Deathmatch". National Geographic Channel. Retrieved April 17, 2014.
(starting at 1 min 49 s): "They have the most toxic venom towards humans then any other snake in the world
- "Facts and Figures: World's Most Venomous Snakes". Australian Venom Research Unit, University of Melbourne. January 11, 2014. Archived from the original on October 11, 2014. Retrieved July 14, 2014.
- "What is an LD50 and LC50". 2018-12-31.
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- Davidson, Terence. "Immediate First Aid – Black Mamba". University of California, San Diego. Retrieved 2010-05-12.
- "Immediate First Aid for bites by Australian taipan or common taipan".