In the Kingdom of Poland, the village of Mosty was a royal property, with its own starostas. The village itself was established in 1472, and was part of Belz Voivodeship. In the late 15th century, Mosty was ransacked and destroyed in a Crimean Tatars raid, and in July 1497, during the Moldavian expedition of John I Albert, a unit of Teutonic Knights under Johann von Tiefen, called upon by the Polish king, marched through the village. On 23 July 1549, during the period known as the Polish Golden Age, Mosty received Magdeburg rights. Following the order of King Zygmunt August, a nobleman Andrzej Rokicki became the first local wojt. Mosty enjoyed several royal privileges, issued in the years 1550, 1553, 1566, 1576, 1583, 1604. The town also became the seat of a starosta.
Until 1772, Mosty remained in Belz Voivodeship. Following the Partitions of Poland, the town became part of Austrian Galicia. In 1846, a complex of military barracks was built in Mosty, and in 1880, the town had the population of almost 4,000. In the Second Polish Republic, the Central Police Academy was located here.
The Jewish population was important in the town before World War II. During World War II, as of June 29, 1941, Germans occupied the town and kept the Jews prisoners in a ghetto using them as forced labour before murdering them all. In early July, 1941, local residents burned 19 Jews in the Synagogue. Throughout the occupation, Ukrainian police assisted in most of the murders of their Jewish neighbors. A Captain Kroupa in the military-engineer division of the Wehrmacht protected Jews from death during the first part of the occupation, employing more than 2000, including 1200 women, and helping forge work permits for some. He was later court-martialed for protecting Jews.
Currently, Mosty has a local branch of the Association of Polish Culture of the Lviv Land. Among people born here are photographer Wlodzimierz Puchalski, mathematician Wlodzimierz Stozek and Austrian painter Siegfried Weyr.
- "Чисельність наявного населення України (Actual population of Ukraine)" (PDF) (in Ukrainian). State Statistics Service of Ukraine. Retrieved 30 September 2020.
- "Mosty Wielkie". Virtual Shtetl. Retrieved 24 March 2020.
- |url=https://www.yadvashem.org/yv/he/research/ghettos_encyclopedia/ghetto_details.asp?cid=573 |website=Yad Vashem |accessdate=24 March 2020 |language=Hebrew}}
- Megargee, Geoffrey (2012). Encyclopedia of Camps and Ghettos. Bloomington, Indiana: University of Indiana Press. p. Volume II, 808–810. ISBN 978-0-253-35599-7.
- Mosty Wielkie Czarnecki, Jerzy (2006). Wiehn, Erhard Roy (ed.). My life as an "Aryan": from Velyki Mosty through Zhovkva to Stralsund (1st ed.). Hartung-Gorre. ISBN 3-89649-998-X.
- Megargee, Geoffrey (2012). Encyclopedia of Camps and Ghettos. Bloomington, Indiana: University of Indiana Press. p. 809. ISBN 978-0-253-35599-7.