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- Sampson Salter Blowers
- Samuel Adams (Loyalist)
- Samuel C. Upham
- Samuel Campbell Clegg
- Samuel Medary
- Samuel Seabury (1729–1796)
- Sandwich Islands
- Santa Fe de Nuevo México
- Saybrook Colony
- Scottish colonization of the Americas
- Seattle General Strike
- Secession in New York
- Secession in the United States
- Second Confederate Congress
- Second Vermont Republic
- Seniority in the United States Senate
- Sewer Socialism
- Share Our Wealth
- Silvester Gardiner
- Simon Girty
- Single bullet theory
- Sir Robert Eden, 1st Baronet, of Maryland
- Slave and free states
- Slave health on American plantations
- Slavery in the colonial United States
- Slavery in the United States
- Socialist Party of America
- Socialist Workers Party (United States)
- South Carolina in the American Revolution
- Southern Democrats
- Southern Unionist
- Southern United States
- Spanish colonization of the Americas
- Spanish Florida
- Spanish Texas
- Spying on United Nations leaders by United States diplomats
- Star Spangled Banner Flag
- State governments of the United States
- State of Franklin
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- States' rights
- Stella (United States coin)
- Stephen A. Douglas
- Superior (proposed U.S. state)
- Swedish colonization of the Americas
- Territory of Alaska
- Territory of Hawaii
- Texas Secession Movement
- Thaddeus Stevens
- Thanks of Congress
- The Crisis (newspaper)
- The Political Cesspool
- The Treason of the Senate
- The World According to Bush
- Thirteen Colonies
- Thomas Brown (loyalist)
- Thomas C. Hindman
- Thomas Henry Barclay
- Thomas Hickey (soldier)
- Thomas Hutchinson (governor)
- Thomas Jefferson and slavery
- Thomas Jones (historian)
- Thomas Nast
- Thomas Welch
- Thoughts on Government
- Three-cent piece (United States coin)
- Three-dollar piece
- Timeline of events leading to the American Civil War
- Timeline of pre–United States history
- Timeline of the American Revolution
- Timeline of the colonization of North America
- Timeline of United States military operations
- Timothy Ruggles
- Timothy Stansbury
- Titles of Nobility Amendment
- Tony Rezko
- Torturing Democracy
- Transylvania (colony)
- Twenty-cent piece (United States coin)
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- Ugly law
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- Uncle Sam
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- United Empire Loyalist
- United States Constitution
- United States diplomatic cables leak
- United States dollar
- United States home front during World War II
- United States Mint
- United States National Register of Historic Places listings
- United States territorial acquisitions
- United States territory
- United States v. Forty Barrels and Twenty Kegs of Coca-Cola
- United States war crimes
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- Upton Sinclair
- Van Staphorst v. Maryland
- Vandalia (colony)
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- Virginia Declaration of Rights
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- William Franklin
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- William McCormick (businessman)
- William Porcher Miles
- William Stark
- William Woods Holden
- Wisconsin Idea
- Wounded Knee Massacre
- Yamasee War
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