USS Nerka may refer to:
- USS Nerka (SS-380), a United States Navy submarine authorized during World War II; her construction contract was canceled in July 1944
- USS Nerka, a fictional World War II submarine of the United States Navy that serves as the setting for the 1958 film Run Silent, Run Deep, an adaptation of the 1955 novel Run Silent, Run Deep.
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.