A two-hander is a term for a play, film, or television programme with only two main characters. The two characters in question often display differences in social standing or experiences, differences that are explored and possibly overcome as the story unfolds.
- The Stronger (1889) by August Strindberg (also dramatic monologue.)
- Pariah (1889) by August Strindberg
- Hughie (1942) by Eugene O'Neill
- Two for the Seesaw (1958) by William Gibson
- The Zoo Story (1959) by Edward Albee
- The Dumb Waiter (1960) by Harold Pinter
- Happy Days (1961) by Samuel Beckett
- The Blood Knot (1961) by Athol Fugard
- Same Time, Next Year (1975) by Bernard Slade
- The Gin Game (1976) by D. L. Coburn
- The Woods (1977) by David Mamet
- Talley's Folly (1980) by Lanford Wilson
- Duet for One (1980, filmed in 1986), by Tom Kempinski
- Educating Rita (1980) by Willy Russell
- Mass Appeal (1980) by Bill C. Davis
- Some Men Need Help (1982) by John Ford Noonan
- The Woman in Black (1987) by Stephen Mallatratt
- The Meeting (1987) by Jeff Stetson
- Love Letters (1988) by A. R. Gurney
- A Walk in the Woods (1988) by Lee Blessing
- Oleanna (1992) by David Mamet
- John & Jen (1995) by Andrew Lippa and Tom Greenwald
- Same Time, Another Year (1995) by Bernard Slade (sequel)
- Disco Pigs (1996) by Enda Walsh
- Stones in His Pockets (1996) by Marie Jones
- Vigil (1996) by Morris Panych
- The Blue Room (1998) by David Hare
- Freud's Last Session (1999) by Mark St. Germain
- Six Dance Lessons in Six Weeks (2001) by Richard Alfieri
- The Last Five Years (2001) by Jason Robert Brown
- A Number (2002) by Caryl Churchill
- Adrenalin...Heart (2002) by Georgia Fitch
- Tuesdays with Morrie (2002) by Mitch Albom and Jeffrey Hatcher
- The Story of My Life (2009) by Neil Bartram and Brian Hill
- A Steady Rain (2007) by Keith Huff
- Follow Me (2008) by Ross Gurney-Randall and Dave Mounfield
- it felt empty when the heart went at first but it is alright now (2009) by Lucy Kirkwood
- Red (2009) by John Logan
- Venus in Fur (2010) by David Ives
- Keeper (2015) by Tanisha Taitt
- In a Forest, Dark and Deep (2011) by Neil LaBute
- Constellations (2012) by Nick Payne
- Between the Sheets (2012) by Jordi Mand
- The Anarchist (2012) by David Mamet
- The Velocity of Autumn (2013) by Eric Coble
- Sex With Strangers (2014) by Laura Eason
- China Doll (2015) by David Mamet
- Guards at the Taj (2015) by Rajiv Joseph
- Sleuth (1972) by Joseph L. Mankiewicz
- My Dinner with Andre (1981) by Louis Malle
- Primer (2004) by Shane Carruth
- Interview (2007) by Steve Buscemi
- Moon (2009) by Duncan Jones
- Breaking Bad episode Fly, featuring Bryan Cranston and Aaron Paul
- Episode 1103 (29 May 1992)
- Episode 2432 (23 May 2001)
- Episode 2570 (19 August 2001)
- Coronation Street
- Episode 4745a (2 January 2000)
- Episode 6519 (25th March 2007)
- Dinner for One (1963) by Lauri Wylie, the most frequently repeated TV programme ever
- EastEnders two-hander episodes
- Emmerdale episode 2754 (28 September 2000) featuring Paddy Kirk (Dominic Brunt) and Mandy Dingle (Lisa Riley).
- Family Guy episodes "Brian & Stewie" and "Send in Stewie, Please."
- Four Star Playhouse episode Award
- Home and Away episode "Episode 6361", featuring Ricky Sharpe and Darryl Braxton.
- Maude; several episodes featured only the characters of Maude and Walter, such as:
- "Maude's Night Out"
- "The Convention"
- Miranda episode "Just Act Normal" (Series 2, episode 5), portrays Miranda and Penny in a therapy session following an unfortunate incident involving ice cream, a policeman, a teacher and their 30 pupils.
- Neighbours episode 8052, featuring Toadfish Rebecchi and Sonya Rebecchi in which the latter dies from cancer.
- Please Like Me: "Scroggin'" (Series 2, episode 7) featured only the characters of Josh (Josh Thomas) and Rose (Debra Lawrance) hiking through the woods following the suicide of their friend. Thomas won an AACTA Award for Best Screenplay in Television for writing the episode and Lawrance won an AACTA Award for Best Performance in a Television Comedy for her portrayal of Rose. The episode also received accolades from both the Australian Writer's Guild and Australian Directors Guild.
- Porridge: "A Night In" (Series 1, episode 3)
- The Twilight Zone episode "Two", featuring Elizabeth Montgomery and Charles Bronson
- Head Case (2007) by Alexandra Wentworth
- Web Therapy (2008) by Lisa Kudrow
- In Treatment (2008) by Rodrigo Garcia
- "Slanguage Dictionary Results - Two-hander". Variety. Retrieved 2008-06-19.
- Wolcott, James (6 September 2010). "Crouching Duck, Hidden Draper: Mad Men Season 4, Episode 7". Vanity Fair. Retrieved 7 September 2010.
- Caption for still from William Gibson’s play “Two for the Seesaw.” Photo credit Arthur Cantor; from "Looking Back at Arthur Penn" slide show; The New York Times, September 30, 2010. Retrieved 2010-10-04.
- "A Walk in the Woods". Playbill. 1988.
- Stasio, Marilyn (30 September 2009). "Vigil".
- Gardner, Lyn (20 October 2009). "It Felt Empty When the Heart Went at First But It Is Alright Now - Theatre review". the Guardian.
- "it felt empty when the heart went at first but it is alright now - Drama Online". www.dramaonlinelibrary.com.
- "Lucy Kirkwood interview: 'I worry a lot about the things I write'".
- "What's On: Between the Sheets", Nightwood Theatre
- "Dramatists Play Service, Inc". www.dramatists.com.