Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions.
|Trade names||Mavik, others|
|Protein binding||Trandolapril 80%|
(independent of concentration)
Trandolaprilat 65 to 94%
|Elimination half-life||6 hours (trandolapril)|
10 hours (trandolaprilat)
|Excretion||Fecal and Kidney|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||430.537 g/mol g·mol−1|
|3D model (JSmol)|
|Melting point||119 to 123 °C (246 to 253 °F)|
Possible drug interactionsEdit
Patients also on diuretics may experience an excessive reduction of blood pressure after initiation of therapy with trandolapril. It can reduce potassium loss caused by thiazide diuretics, and increase serum potassium when used alone. Therefore, hyperkalemia is a possible risk. Increased serum lithum levels can occur in patients who are also on lithium.
Contraindications and precautionsEdit
Pregnancy and lactationEdit
Trandolapril is teratogenic (US: pregnancy category D) and can cause birth defects and even death of the developing fetus. The highest risk to the fetus is during the second and third trimesters. When pregnancy is detected, trandolapril should be discontinued as soon as possible. Trandolapril should not be administered to nursing mothers.
Trandolapril is a prodrug that is de-esterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin–angiotensin–aldosterone system. Trandolapril has a half-life of about 6 hours, and trandolaprilat has a half life of about 10 h. Trandolaprilat has about eight times the activity of its parent drug. About one-third of trandolapril and its metabolites are excreted in the urine, and about two-thirds of trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.
Mode of actionEdit
- Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495.
- Tan, X; He, W; Liu, Y (2009). "Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy". Kidney International. 76 (12): 1248–57. doi:10.1038/ki.2009.346. PMID 19759524.
- Trandolapril Information - rxlist.com (Rxlist.com, The Internet Drug Index)