Louiso directed his first film in 2002, the acclaimed Love Liza with Philip Seymour Hoffman. He has had supporting roles in films like The Rock, Apollo 13, Jerry Maguire, Scent of a Woman and Thank You for Smoking.
In 2012, his film Hello I Must Be Going was selected as the opening night film of the Sundance Film Festival. His adaptation of Macbeth, written along with his brother-in-law Jacob Koskoff, was released in 2015 as a feature film starring Michael Fassbender and Marion Cotillard.
Louiso is married to screenwriter Sarah Koskoff, who wrote the script for Hello I Must Be Going.
|1990||Stella||Preppy Boy # 1|
|1991||Billy Bathgate||Bell Boy at Racetrack|
|1992||Scent of a Woman||Trent Potter|
|1995||The Fifteen Minute Hamlet||Ophelia||also director|
|1995||Apollo 13||FAO White|
|1996||The Rock||Marvin Isherwood|
|1996||Jerry Maguire||Chad the Nanny|
|1997||8 Heads in a Duffel Bag||Steve|
|1998||A Cool, Dry Place||Bob Harper|
|2001||The Cutting Room||Jason||Short|
|2005||xXx: State of the Union||Dickie Ambrose||Uncredited|
|2005||Thank You for Smoking||Ron Goode|
|2006||Snakes on a Plane||Dr. Steven Price|
|2006||School for Scoundrels||Eli|
|2007||Meet Bill||John Jr.|
|2011||A Bag of Hammers||Marty|
|2014||Imperial Dreams||Peter Hall|
|2017||The Last Word||Dr. Morgan|
|2018||All About Nina||Smoky|
|1984–1985||Young People's Specials||Brian (1984), Jake (1985)||Episode: "That Funny Fat Kid" (1984), "Narc" (1985)|
|1987||ABC Afterschool Specials||various characters|
|1995||The Critic||Johnny Wratch||voice, episode: A song for Margo|
|1995||Letter to My Killer (TV Movie)||Bradley|
|1995||Iron Man||The Hacker||voice, season 2 episode 6: Iron Man, on the inside|
|1995||Aaahh!! Real Monsters||Man/Teenager||voice, season 2 episode 9: Rosh O'Monster/The Tree of Ickins|
|1997||Fired Up||Little H.||Season 1 episode 2: The Next Day|
|1998–1999||Chicago Hope||Andy Sparks|
|2004||Joan of Arcadia||Mr. Smith||Season 1 episode 18: Requiem for a Third Grade Ashtray|
|2004||Frasier||Jonathan||Season 11 episode 21: Detour|
|2004||Century City||Dave Pappas||Season 1 episode 6: Without a Tracer|
|2004||Without a Trace||Ned Atkins||Season3 episode 8: Doppelganger: Part 2|
|2005||Everwood||Equipment Buyer||Season 3 episode 20: He Who Hesitates|
|2008||House||Stewart Nozick||Season 5 episode 7: "The Itch"|
|2009||In Plain Sight||Dennis Sampson/ Dennis Stewart||Season 2 episode 8: A Frond in Need|
|2009||Medium||Troy Sanborn||Season 6 episode 7: New Terrain|
|2010||The Good Guys||The Duke||Season 1 episode 9: Don't Tase Me, Bro|
|2011||Californication||Director||Season 4 episode 8: Lights, Camera, Asshole|
|2011||Off the Map||Greg Clemmons||Season 1 episode 9: There's Nothing to Fix|
|2018||Silicon Valley||Ariel Eklow||Season 5 episode 5: Facial Recognition|
|1995||The Fifteen Minute Hamlet||Short|
|2009||The Marc Pease Experience|
|2012||Hello I Must Be Going|
- "Love Notes: FFC Interviews Todd Louiso and Philip Seymour Hoffman". filmfreakcentral.net. Retrieved 2019-11-01.
- "Sundance: 'Hello I Must Be Going' Director Todd Louiso On Working With Melanie Lynskey, Quitting Acting & The Influence Of Judd Apatow". indiewire.com. Retrieved 2019-11-01.
- "Review: 'Macbeth,' Starring Michael Fassbender, Awash in Gorgeous Carnage". nytimes.com. Retrieved 2019-11-01.
- Barone, Meg (September 1, 2012). "Westport showcased in town native's film, 'Hello I Must Be Going'". Westport News. Retrieved September 2, 2019.